{"id":"W2792613404","doi":"10.1074/jbc.ra118.002703","title":"Kv2.1 clusters on β-cell plasma membrane act as reservoirs that replenish pools of newcomer insulin granule through their interaction with syntaxin-3","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research","keywords":"Exocytosis; Cell biology; Secretion; Granule (geology); Syntaxin; Total internal reflection fluorescence microscope; Syntaxin 3; Secretory protein; Chemistry; Biology; Membrane; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001805306,0.0002959252,0.0004104759,0.0001917874,0.0002436855,0.0006586955,0.000390557,0.0003360944,0.001484096],"category_scores_gemma":[0.0001681074,0.000257734,0.0003292393,0.0001244941,0.0002362599,0.0008650759,0.0005777734,0.0007299563,0.0005079909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000506112,"about_ca_system_score_gemma":0.0002197505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004303851,"about_ca_topic_score_gemma":0.0006401852,"domain_scores_codex":[0.9998436,0.00001718921,0.00001260052,0.00005307075,0.00003154944,0.00004191817],"domain_scores_gemma":[0.9998374,0.00001312454,0.00003448359,0.0000197317,0.00002256061,0.00007277578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003127189,0.000008065407,0.0002267143,0.0000276101,0.000007375621,0.00005218209,0.00001700801,0.00004042558,0.9986058,0.0001554714,0.00006161285,0.0004849753],"study_design_scores_gemma":[0.0001006228,0.0001705966,0.006112038,0.000008458471,0.00003442216,0.0003799427,0.00009042068,0.001517606,0.9883984,0.00020198,0.002973052,0.0000124992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945222,0.001089281,0.0031224,0.0001580792,0.00009414204,0.000009791963,0.000240999,0.000123661,0.0006394061],"genre_scores_gemma":[0.9953709,0.0003263819,0.001610093,0.00004213053,0.00002073756,0.00001525816,0.000369941,0.00007004263,0.002174355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001484096,"threshold_uncertainty_score":0.004964769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02691927734463447,"score_gpt":0.2527515625282216,"score_spread":0.2258322851835871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}