{"id":"W2792646397","doi":"10.1093/jcag/gwy009.157","title":"A157 THE THRESHOLD FOR INFLIXIMAB TROUGH LEVELS LEADING TO DOSE ESCALATION DIFFERS BETWEEN CROHN’S DISEASE AND ULCERATIVE COLITIS","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Infliximab; Therapeutic drug monitoring; Ulcerative colitis; Trough level; Retrospective cohort study; Confidence interval; Internal medicine; Disease; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002148715,0.0001313741,0.0003388613,0.001492439,0.000465918,0.001078839,0.0003289039,0.0003953,0.001801104],"category_scores_gemma":[0.01498837,0.0001624295,0.0004130335,0.002186289,0.0005711091,0.0004923189,0.0003842573,0.0004579269,0.0001833468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001867015,"about_ca_system_score_gemma":0.00220946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02171535,"about_ca_topic_score_gemma":0.03112055,"domain_scores_codex":[0.9957775,0.0009734558,0.0007558865,0.0004933659,0.001552159,0.0004475269],"domain_scores_gemma":[0.9851025,0.00464969,0.008154364,0.0003654773,0.0009572497,0.0007707383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003010588,0.00003161655,0.9877654,0.00006277623,0.00002359976,0.000276103,0.0001859121,0.00009742986,0.0003979141,0.00009655215,0.0003011682,0.01046037],"study_design_scores_gemma":[0.00001447744,0.0001419979,0.9966899,0.00007037765,0.0000261189,0.00131136,0.0003474732,0.0002191715,0.0002521556,0.00005178842,0.0008698511,0.000005396837],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935095,0.002095723,0.000466183,0.0003442964,0.0000232884,0.00004740308,0.0005001812,0.00001148624,0.003002014],"genre_scores_gemma":[0.9986727,0.0003126573,0.0004733966,0.0001000868,0.00001191137,0.00001636216,0.0003037878,0.000003083297,0.0001060659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02171535,"threshold_uncertainty_score":0.0431779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01303484600689931,"score_gpt":0.2522703017917131,"score_spread":0.2392354557848138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}