{"id":"W2792685524","doi":"10.1093/jcag/gwy008.302","title":"A301 GUT MICROBIOTA FROM A PATIENT WITH GENERALIZED ANXIETY DISORDER INDUCES ANXIETY-LIKE BEHAVIOUR AND ALTERED BRAIN CHEMISTRY IN GNOTOBIOTIC MICE","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Anxiety; Generalized anxiety disorder; Pathophysiology; Gut–brain axis; Gut flora; Depression (economics); Feces; Internal medicine; Immunology; Medicine; Biology; Endocrinology; Psychiatry; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001145061,0.0005067639,0.0003822861,0.0003989987,0.0002578247,0.0002889729,0.0001192689,0.0004416532,0.002147285],"category_scores_gemma":[0.0001771141,0.0002445366,0.0004799439,0.0002046333,0.0003172114,0.0001934237,0.0004089598,0.0009619724,0.0002984233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000213932,"about_ca_system_score_gemma":0.000170834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005649867,"about_ca_topic_score_gemma":0.0009260058,"domain_scores_codex":[0.9997701,0.00003212629,0.00002257818,0.00007603534,0.00004132224,0.00005780267],"domain_scores_gemma":[0.9998285,0.00001128114,0.00003957542,0.00001863414,0.00001000686,0.00009204185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002463336,0.0006300296,0.004746033,0.0000837292,0.00005090623,0.0009281816,0.0001227288,0.00003872561,0.9874043,0.00008276454,0.0002649683,0.003184328],"study_design_scores_gemma":[0.001102144,0.03652643,0.6188385,0.0001402967,0.0003706013,0.02653509,0.001561464,0.002263693,0.3035363,0.0005155971,0.008530954,0.00007895265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985753,0.0002538387,0.0002430186,0.0001373963,0.00003694182,0.00002163004,0.0003285133,0.00002900476,0.0003743405],"genre_scores_gemma":[0.9968162,0.0003860395,0.000732708,0.0002825719,0.00001585081,0.000042558,0.000702943,0.00001581759,0.001005257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002147285,"threshold_uncertainty_score":0.007183373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003526766348600615,"score_gpt":0.2008007126239577,"score_spread":0.197273946275357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}