{"id":"W2792693788","doi":"10.1093/hmg/ddy021","title":"Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation","year":2018,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Division of Materials Research; Canadian Institutes of Health Research","keywords":"Methylenetetrahydrofolate reductase; Biology; DNA methylation; Sperm; Methylation; Endocrinology; Internal medicine; Andrology; Genetics; Gene; Gene expression; Medicine; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003005992,0.0002157701,0.0002291602,0.0002547636,0.0002236229,0.00006246167,0.0001392393,0.0001293622,0.0004561996],"category_scores_gemma":[0.0001473364,0.0001888902,0.00006555714,0.0005434032,0.0002008961,0.00005218343,0.00006256543,0.0001745651,0.0001078759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001440274,"about_ca_system_score_gemma":0.0001122971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005879898,"about_ca_topic_score_gemma":0.0001024379,"domain_scores_codex":[0.9979533,0.0001197979,0.0002995799,0.0003875836,0.0007705149,0.0004692022],"domain_scores_gemma":[0.9988539,0.00002999959,0.0001017051,0.0004416612,0.000399056,0.0001736994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006839519,0.0003253465,0.01316017,0.00003166438,0.0001087924,0.0001867212,0.0004560755,0.00002424237,0.9830337,0.0005242418,0.0004244498,0.001656265],"study_design_scores_gemma":[0.004330697,0.004546326,0.4178862,0.0001008159,0.0003143723,0.00004269639,0.0001541078,0.0006044875,0.5702799,0.0006117216,0.0007430187,0.0003856809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949471,0.0002815561,0.002169566,0.0001666414,0.00004488394,0.000617391,0.00001638605,0.00006112945,0.001695335],"genre_scores_gemma":[0.9955522,0.00002478656,0.00303251,0.0003285102,0.0001210432,0.00002924532,0.0004942637,0.00005787912,0.000359607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4127537,"threshold_uncertainty_score":0.7702721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03013524726260779,"score_gpt":0.3204235271801038,"score_spread":0.290288279917496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}