{"id":"W2792693788","doi":"10.1093/hmg/ddy021","title":"Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation","year":2018,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Division of Materials Research; Canadian Institutes of Health Research","keywords":"Methylenetetrahydrofolate reductase; Biology; DNA methylation; Sperm; Methylation; Endocrinology; Internal medicine; Andrology; Genetics; Gene; Gene expression; Medicine; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001403624,0.0002443241,0.0003479785,0.0005391473,0.0001613603,0.0001299829,0.0002752933,0.0003846898,0.002147342],"category_scores_gemma":[0.0002085869,0.0001237539,0.0002510273,0.0003928269,0.0002767642,0.00009519444,0.0001512473,0.0003506976,0.0001958539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000237228,"about_ca_system_score_gemma":0.0001421906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001285875,"about_ca_topic_score_gemma":0.001150051,"domain_scores_codex":[0.9999155,0.00001726871,0.000007257952,0.00002442917,0.00001888504,0.00001670862],"domain_scores_gemma":[0.9998736,0.00001548496,0.00005295904,0.00001398748,0.0000117778,0.00003211709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001807602,0.000105271,0.09563768,0.0002513952,0.000153312,0.00870791,0.0001917265,0.0002139978,0.8811044,0.0004482183,0.0003162182,0.01106235],"study_design_scores_gemma":[0.0001238476,0.002393074,0.6836739,0.00004502315,0.0004094905,0.04683704,0.0002359033,0.001468362,0.2577794,0.0007254085,0.006285121,0.00002348609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994635,0.002578093,0.001353208,0.0001866581,0.00001765662,0.00002338141,0.0002815098,0.0001059608,0.0008186252],"genre_scores_gemma":[0.9981627,0.0005767246,0.0002970545,0.00005518089,0.00001205068,0.0000055526,0.0001834327,0.000008883409,0.0006984232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002147342,"threshold_uncertainty_score":0.007183611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03013524726260779,"score_gpt":0.3204235271801038,"score_spread":0.290288279917496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}