{"id":"W2792703627","doi":"10.1016/j.bbrc.2018.02.208","title":"Partial loss of complex I due to NDUFS4 deficiency augments myocardial reperfusion damage by increasing mitochondrial superoxide/hydrogen peroxide production","year":2018,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Memorial University of Newfoundland; Research and Development Corporation of Newfoundland and Labrador","keywords":"Reactive oxygen species; Mitochondrion; Superoxide; Hydrogen peroxide; Chemistry; Electron Transport Complex I; Reperfusion injury; Internal medicine; Mitochondrial ROS; Endocrinology; Biochemistry; Respiratory chain; Ischemia; Biology; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006913172,0.0001848198,0.0004120011,0.0001398666,0.0005446527,0.00003573465,0.000414288,0.0001827719,0.00003123503],"category_scores_gemma":[0.001582484,0.0001497554,0.000168253,0.0007624054,0.001822144,0.0000809353,0.0009943407,0.0004851723,0.00004197603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000113913,"about_ca_system_score_gemma":0.0001499113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000389409,"about_ca_topic_score_gemma":0.000003756133,"domain_scores_codex":[0.9973433,0.0003709445,0.0004160714,0.0005415039,0.0008684887,0.0004596875],"domain_scores_gemma":[0.9971234,0.0002924754,0.00005882929,0.001382041,0.0007036562,0.0004396234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006963185,0.0007458259,0.0004531737,0.00004710631,0.00002475292,0.000002376456,0.0002635041,6.992909e-8,0.9905614,0.0001509448,0.005281609,0.001772942],"study_design_scores_gemma":[0.0006474603,0.0005248138,0.002011592,0.0001787149,0.00005978103,0.00004280631,0.000153575,0.0001677642,0.9918703,0.00007260868,0.004109232,0.0001613568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936179,0.0002531887,0.00005171245,0.00451405,0.00007917536,0.0007384535,0.0000467533,0.00004177121,0.0006570092],"genre_scores_gemma":[0.9953709,0.0002463131,0.003204385,0.00007821545,0.0007026534,0.00006141251,0.000187071,0.00002211247,0.000126895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004435835,"threshold_uncertainty_score":0.6713765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05357802200017894,"score_gpt":0.3603560463271475,"score_spread":0.3067780243269685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}