{"id":"W2792706300","doi":"10.1016/j.nbd.2018.02.004","title":"The AMPK-PGC-1α signaling axis regulates the astrocyte glutathione system to protect against oxidative and metabolic injury","year":2018,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Glaucoma Research Society of Canada","keywords":"AMPK; Astrocyte; GCLM; Cell biology; Biology; Oxidative stress; Glutathione; Chemistry; Protein kinase A; Biochemistry; Neuroscience; Kinase; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000166191,0.0003048457,0.0003071902,0.0003784492,0.0003552396,0.0005689833,0.0002061943,0.0003591983,0.001485684],"category_scores_gemma":[0.0001286144,0.0001740531,0.0003391695,0.0002028295,0.0003796942,0.0004415508,0.0005089692,0.0006345254,0.0004150184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003603859,"about_ca_system_score_gemma":0.0004553239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006250103,"about_ca_topic_score_gemma":0.001633263,"domain_scores_codex":[0.9998609,0.00002335674,0.000009135139,0.00002939358,0.00002789717,0.00004925372],"domain_scores_gemma":[0.9999202,0.000002788171,0.00002262373,0.000007063811,0.00002504217,0.00002220992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00146468,0.0001120951,0.003949311,0.0003418537,0.000145857,0.0003540746,0.0001657563,0.0004139031,0.9646247,0.003146074,0.001264841,0.02401695],"study_design_scores_gemma":[0.0003334127,0.001527005,0.132808,0.0002179387,0.0004772352,0.001351746,0.001047135,0.004241321,0.8053176,0.009686148,0.04293113,0.0000613755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9585944,0.01972329,0.009998213,0.002681265,0.0005086217,0.00006108224,0.0006407969,0.0002713266,0.007520972],"genre_scores_gemma":[0.9894756,0.004769117,0.001957159,0.0002499774,0.00006834745,0.00002550467,0.0002432366,0.00003020983,0.003180844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001485684,"threshold_uncertainty_score":0.004970074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531261927344802,"score_gpt":0.2469558983889809,"score_spread":0.2316432791155329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}