{"id":"W2792707600","doi":"10.1371/journal.pntd.0006344","title":"Experimental Chagas disease-induced perturbations of the fecal microbiome and metabolome","year":2018,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Canadian Institutes of Health Research; University of California, San Diego; National Institutes of Health; European Bioinformatics Institute","keywords":"Metabolome; Chagas disease; Biology; Trypanosoma cruzi; Lachnospiraceae; Microbiome; Metabolomics; Gut flora; Feces; Triatominae; Microbiology; Immunology; Bioinformatics; Parasite hosting; Bacteria; Reduviidae; Zoology; Genetics; 16S ribosomal RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[4.903757e-7,0.0001339795,0.0002176748,0.0000898607,0.0002210644,0.00002549211,0.0001424563,0.00004357478,0.0005078914],"category_scores_gemma":[0.0005562151,0.00008655731,0.0001336878,0.0004040442,0.0006090603,0.00007343243,0.0001215922,0.0001157296,0.00002864827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004620439,"about_ca_system_score_gemma":0.0001750594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009240525,"about_ca_topic_score_gemma":0.000002836439,"domain_scores_codex":[0.9989007,0.00007234262,0.0001994761,0.0002642587,0.0002957659,0.0002674485],"domain_scores_gemma":[0.998794,0.00008964646,0.00004510743,0.0004159074,0.0001808481,0.0004745107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002366999,0.0009466463,0.006993966,0.00003526731,0.00009642474,0.000002814559,0.00006039634,1.401445e-8,0.9887835,0.001434633,0.00125456,0.0001550889],"study_design_scores_gemma":[0.0007744957,0.000295057,0.9235069,0.00005015608,0.0001734923,0.000008422718,0.00003910307,0.00007975538,0.07406189,0.00009472699,0.000835835,0.00008019948],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945825,0.001021453,0.00002059055,0.003169508,0.00004953286,0.0005274029,0.0002285484,0.00006368649,0.0003367203],"genre_scores_gemma":[0.9988673,0.00002656173,0.0001076406,0.0003148816,0.0002269251,0.00008226819,0.00003845678,0.0000178328,0.0003180788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9165129,"threshold_uncertainty_score":0.5561055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02686158310708085,"score_gpt":0.2884953030740697,"score_spread":0.2616337199669889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}