{"id":"W2792709310","doi":"10.1158/1538-7445.sabcs17-p2-09-10","title":"Abstract P2-09-10: Comprehensive gene expression biomarker analysis of CDK 4/6 and endocrine pathways from the PALOMA-2 study","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Palbociclib; Biomarker; Internal medicine; Cyclin-dependent kinase; Oncology; Cancer; Medicine; Letrozole; Gene expression; Cancer research; Biology; Gene; Breast cancer; Cell cycle; Metastatic breast cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001711018,0.0005621854,0.0006885732,0.0003550363,0.0003126274,0.0007883616,0.0005700554,0.0003669413,0.002500126],"category_scores_gemma":[0.0008378098,0.0002637953,0.000605772,0.0006688626,0.0003077445,0.0002484778,0.0006537826,0.0008531383,0.0007080471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003374636,"about_ca_system_score_gemma":0.001098378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001400544,"about_ca_topic_score_gemma":0.003595555,"domain_scores_codex":[0.9995643,0.000191424,0.00002013378,0.00009506397,0.00008365748,0.00004538326],"domain_scores_gemma":[0.9993178,0.0001270964,0.0001274805,0.00009922805,0.0001208872,0.000207581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2226029,0.005088476,0.5147138,0.001583311,0.006086555,0.001310106,0.0003389891,0.00293277,0.09760945,0.0003590953,0.03811487,0.1092597],"study_design_scores_gemma":[0.02712199,0.01971034,0.9107886,0.0001165254,0.004265485,0.00169805,0.0002716183,0.002106032,0.01044832,0.0004790059,0.02292231,0.00007161128],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9530624,0.002522388,0.001444439,0.0006800639,0.00005428888,0.0009172557,0.03699546,0.000110555,0.004213094],"genre_scores_gemma":[0.9060003,0.001012832,0.002789545,0.001002988,0.0001407813,0.001713617,0.08419738,0.00007448794,0.003068201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002500126,"threshold_uncertainty_score":0.00904882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1635783594928865,"score_gpt":0.4464824614363966,"score_spread":0.28290410194351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}