{"id":"W2792711877","doi":"10.1016/j.jconrel.2018.01.024","title":"In vitro models and systems for evaluating the dynamics of drug delivery to the healthy and diseased brain","year":2018,"lang":"en","type":"review","venue":"Journal of Controlled Release","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Alberta Innovates; Qatar University; American University of Beirut; National Council for Scientific Research; Qatar Foundation","keywords":"Drug delivery; Blood–brain barrier; Brain function; Neuroscience; Drug delivery to the brain; Targeted drug delivery; Function (biology); Nanotechnology; Computer science; Biology; Central nervous system; Materials science; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002363157,0.0002355298,0.001688118,0.0001870339,0.0002579558,0.00007578009,0.0002579849,0.0000754119,8.843748e-7],"category_scores_gemma":[0.00260126,0.0001033392,0.0003466043,0.0002093345,0.0001350013,0.0001122114,0.00006999393,0.0003437784,2.704813e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007484039,"about_ca_system_score_gemma":0.0003910481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001559681,"about_ca_topic_score_gemma":0.0000133296,"domain_scores_codex":[0.9970351,0.001012261,0.001132719,0.0002207392,0.0003804742,0.0002187081],"domain_scores_gemma":[0.9933091,0.004676558,0.001402575,0.0002119802,0.0002553045,0.0001445106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.04907344,0.0002011235,0.000005652651,0.02141477,0.001218317,0.00005742934,0.003077592,0.001653535,0.0002744613,0.003358853,0.01795859,0.9017062],"study_design_scores_gemma":[0.03945836,0.003536558,0.000009302411,0.01266449,0.00687511,0.0008166289,0.001587412,0.521311,0.00001154179,0.004239809,0.4084991,0.0009907013],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001813316,0.9909284,0.001223898,0.002790336,0.0008112259,0.0022908,0.0001198941,0.000002867116,0.00001933963],"genre_scores_gemma":[0.02262298,0.9752544,0.00003947775,0.001326816,0.0004419813,0.0001257521,8.173361e-7,0.00002430046,0.0001634943],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9007155,"threshold_uncertainty_score":0.4214052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06785337597584748,"score_gpt":0.3643769543354853,"score_spread":0.2965235783596378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}