{"id":"W2792714325","doi":"10.1503/cmaj.69340","title":"Access to new drugs for rare disorders in Canada","year":2018,"lang":"en","type":"letter","venue":"Canadian Medical Association Journal","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Armed Forces; Fraser Institute","funders":"","keywords":"Orphan drug; Government (linguistics); Medicine; Political science; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006964857,0.0002295186,0.000491588,0.0005147214,0.000143409,0.0001231585,0.0005776523,0.0008200268,0.004269044],"category_scores_gemma":[0.002697557,0.0002203385,0.000173766,0.0004063523,0.00002392641,0.0000526958,0.00004091493,0.002887405,0.00005180746],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.005725405,"about_ca_system_score_gemma":0.09232724,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9405395,"about_ca_topic_score_gemma":0.9985521,"domain_scores_codex":[0.9952985,0.0001435114,0.0005196981,0.000334645,0.002574248,0.001129393],"domain_scores_gemma":[0.9961634,0.0002481962,0.00015897,0.0001922182,0.0004207598,0.002816464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001310968,0.000005216629,0.014297,0.00004698132,0.00009362329,0.0005264881,0.00008125172,9.467072e-7,1.765905e-7,5.113527e-7,0.9400852,0.04484944],"study_design_scores_gemma":[0.001536517,0.00007863317,0.006448771,0.0002068056,0.00003803384,0.00008230084,0.0001071998,0.00002740305,0.000001981552,0.00009538048,0.9911742,0.0002028304],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003544737,0.0001989772,0.0001318579,0.9918241,0.001284407,0.0008962076,0.00009210449,0.000005761841,0.002021878],"genre_scores_gemma":[0.001066493,0.0002383633,0.0001012394,0.9798909,0.01125873,0.00004894146,0.0001478164,0.0000691778,0.007178353],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.08660183,"threshold_uncertainty_score":0.999413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01355665546348953,"score_gpt":0.2874318488532067,"score_spread":0.2738751933897172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}