{"id":"W2792728184","doi":"10.1016/j.ceca.2018.02.006","title":"The hidden potential of lysosomal ion channels: A new era of oncogenes","year":2018,"lang":"en","type":"review","venue":"Cell Calcium","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Beatrice Hunter Cancer Research Institute","keywords":"Ion channel; Lysosome; Cell biology; Intracellular; Chemistry; Organelle; Extracellular; Ion transporter; Membrane potential; Biophysics; Biology; Biochemistry; Membrane; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003414136,0.0003614868,0.0009385009,0.00005414907,0.00008914748,0.00002454036,0.0005998366,0.0004815835,0.00003380206],"category_scores_gemma":[0.00006288844,0.0002474717,0.0009237984,0.0001552499,0.0002272736,0.000001908289,0.0002629402,0.0002203226,0.00002686078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001106707,"about_ca_system_score_gemma":0.0004821751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007066786,"about_ca_topic_score_gemma":0.000004204934,"domain_scores_codex":[0.9981012,0.0001976649,0.0007045711,0.0004378784,0.000241317,0.0003173611],"domain_scores_gemma":[0.9983377,0.00003939281,0.0006130536,0.0007210516,0.0001655278,0.0001233158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001607531,0.0001723399,0.000001970519,0.006201616,0.0005301107,0.000008284012,0.00006836758,0.000005376692,0.1006469,0.0000708845,0.02437362,0.8677598],"study_design_scores_gemma":[0.0002527377,0.0002070557,0.000001262939,0.0007301586,0.0005511272,0.00001976738,0.00001253379,0.000002945302,0.07898179,0.00003226979,0.9189651,0.0002432205],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002490831,0.9946067,0.0003034247,0.00001818333,0.001814408,0.0003206135,0.000058506,0.000008394351,0.000378947],"genre_scores_gemma":[0.002201321,0.9906555,0.0001521123,0.00001553925,0.003752808,0.00001477199,0.0001800706,0.00006923899,0.00295861],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8945915,"threshold_uncertainty_score":0.9999977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02949031321254203,"score_gpt":0.2936230962152248,"score_spread":0.2641327830026828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}