{"id":"W2792728184","doi":"10.1016/j.ceca.2018.02.006","title":"The hidden potential of lysosomal ion channels: A new era of oncogenes","year":2018,"lang":"en","type":"review","venue":"Cell Calcium","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Beatrice Hunter Cancer Research Institute","keywords":"Ion channel; Lysosome; Cell biology; Intracellular; Chemistry; Organelle; Extracellular; Ion transporter; Membrane potential; Biophysics; Biology; Biochemistry; Membrane; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006296881,0.0005353137,0.0009093939,0.001223578,0.0002897995,0.001325515,0.0007497922,0.001358417,0.002865815],"category_scores_gemma":[0.001005601,0.0001338497,0.000318322,0.00104639,0.001195398,0.002553205,0.0009014798,0.002202492,0.000946281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000747516,"about_ca_system_score_gemma":0.001154725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000378508,"about_ca_topic_score_gemma":0.0007913177,"domain_scores_codex":[0.9998299,0.00003394503,0.00001834808,0.00002714062,0.00006373805,0.00002684853],"domain_scores_gemma":[0.9995073,0.0002782354,0.00004474218,0.00001871683,0.0001006269,0.00005026221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002033542,0.0000584359,0.0003692408,0.008505046,0.00007294791,0.0007598929,0.0002103571,0.0004657534,0.00577719,0.0468662,0.07455458,0.862157],"study_design_scores_gemma":[0.0000119697,0.00003765806,0.0002488644,0.0009746994,0.00003695506,0.00114419,0.00008561562,0.00008745197,0.0007310827,0.01088355,0.9857438,0.00001404389],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002320889,0.9955793,0.0003259761,0.002203212,0.0005995273,0.000001667518,0.00001746483,0.00001273239,0.00102804],"genre_scores_gemma":[0.002420429,0.9942166,0.0002481641,0.001103204,0.001142218,0.000003691,0.00002532875,0.000003204668,0.0008372288],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002865815,"threshold_uncertainty_score":0.009587109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02949031321254203,"score_gpt":0.2936230962152248,"score_spread":0.2641327830026828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}