{"id":"W2792738569","doi":"10.1007/s00401-018-1826-y","title":"cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant","year":2018,"lang":"en","type":"letter","venue":"Acta Neuropathologica","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":409,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Anaplastic astrocytoma; Astrocytoma; Glioma; Mutant; Pathology; Medicine; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0003277928,0.001621559,0.002055024,0.000781418,0.0006396652,0.0003326331,0.0006793321,0.001377071,0.0002131839],"category_scores_gemma":[0.004285961,0.001212679,0.0005988828,0.0006885002,0.0007077861,0.0002032516,0.0004048637,0.002053563,0.0003179956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002575341,"about_ca_system_score_gemma":0.0002300564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006692853,"about_ca_topic_score_gemma":0.0000295807,"domain_scores_codex":[0.9933171,0.0004199676,0.001330045,0.002322822,0.0008603609,0.001749696],"domain_scores_gemma":[0.9923784,0.00341968,0.0009185225,0.00204314,0.0005606837,0.000679618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003151336,0.005698447,0.006905905,0.0009473636,0.0009024177,0.06721857,0.0002120292,0.00000257473,0.07806713,0.00005193274,0.8351706,0.001671673],"study_design_scores_gemma":[0.0270918,0.02915204,0.07889566,0.001354092,0.007040678,0.01967806,0.0000699414,0.0004176634,0.01787477,0.0003532473,0.8151562,0.002915877],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7895634,0.000672035,0.0002459455,0.2016763,0.0008202536,0.003824493,0.002588528,0.000524871,0.00008417214],"genre_scores_gemma":[0.8736058,0.001332246,0.001898805,0.114345,0.003484743,0.001773537,0.002958357,0.0003765175,0.0002249504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08733128,"threshold_uncertainty_score":0.9999194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02422613144784134,"score_gpt":0.2665187520279247,"score_spread":0.2422926205800834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}