{"id":"W2792738569","doi":"10.1007/s00401-018-1826-y","title":"cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant","year":2018,"lang":"en","type":"letter","venue":"Acta Neuropathologica","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":409,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Anaplastic astrocytoma; Astrocytoma; Glioma; Mutant; Pathology; Medicine; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009060221,0.0008427294,0.0009799812,0.001326752,0.001747887,0.001662918,0.001519796,0.01527119,0.004512487],"category_scores_gemma":[0.01156797,0.0005259665,0.001005627,0.0007023069,0.001258976,0.001930515,0.0009370873,0.006952412,0.002999805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002792721,"about_ca_system_score_gemma":0.001953019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005431578,"about_ca_topic_score_gemma":0.009006437,"domain_scores_codex":[0.9990743,0.0001683243,0.0002237445,0.0001128611,0.000212329,0.0002082915],"domain_scores_gemma":[0.9974935,0.0009949058,0.0001910287,0.0001260995,0.0005734372,0.0006211307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002953762,0.000141562,0.01970385,0.0002582876,0.00005034329,0.2302169,0.0002852181,0.0005755444,0.001744221,0.002932194,0.6996297,0.04416668],"study_design_scores_gemma":[0.0003079371,0.0002434547,0.01760396,0.001009812,0.0002313476,0.567304,0.00088694,0.003461404,0.002328213,0.01204767,0.3944651,0.0001102648],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.03597901,0.01347591,0.002630228,0.8836823,0.02773748,0.0002464569,0.001607788,0.0005008305,0.03413996],"genre_scores_gemma":[0.2752066,0.01944952,0.0103284,0.5163799,0.1517459,0.0004118335,0.003299422,0.0003664258,0.02281202],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.01527119,"threshold_uncertainty_score":0.02026266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02422613144784134,"score_gpt":0.2665187520279247,"score_spread":0.2422926205800834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}