{"id":"W2792747407","doi":"10.3390/molecules23030708","title":"Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols","year":2018,"lang":"en","type":"article","venue":"Molecules","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Glycomics Network; Österreichischen Akademie der Wissenschaften","keywords":"Cyclopentanes; Hydroxymethyl; Stereochemistry; Chemistry; Amine gas treating; Hexosaminidase; Propanoic acid; Biochemistry; Enzyme; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001982699,0.0005672085,0.0005273446,0.00008846659,0.0003213041,0.0001719264,0.000620492,0.00038516,0.002821135],"category_scores_gemma":[0.0002942079,0.0005620557,0.0003106066,0.0003499061,0.0005426263,0.0001987969,0.0002611524,0.0003497024,0.0006157149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001722572,"about_ca_system_score_gemma":0.0001002891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007904071,"about_ca_topic_score_gemma":0.00002232945,"domain_scores_codex":[0.9971292,0.00005079839,0.0006302529,0.0008871754,0.0005384091,0.0007641784],"domain_scores_gemma":[0.998107,0.0001230086,0.0002255052,0.001057231,0.0001732955,0.0003139849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000085051,0.000179324,0.0003145494,0.0001172316,0.0001215776,0.0002331788,0.0002500777,0.00001045761,0.9909009,0.00006541064,0.003339276,0.004382975],"study_design_scores_gemma":[0.0006782456,0.00004566798,0.0001123723,0.0001640329,0.00009181363,0.00009369167,0.0003002168,0.0003494978,0.9529667,0.00009535425,0.04443472,0.0006676182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9198253,0.0004524143,0.0002088135,0.0003826135,0.0003610452,0.0001290386,0.0001118342,0.0003669747,0.07816198],"genre_scores_gemma":[0.9935958,0.00007317121,0.0008337123,0.0002887856,0.001413828,0.00007809392,0.0001855167,0.00009047874,0.003440601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07472138,"threshold_uncertainty_score":0.9996831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316076215245445,"score_gpt":0.2314827980399759,"score_spread":0.2183220358875214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}