{"id":"W2792747407","doi":"10.3390/molecules23030708","title":"Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols","year":2018,"lang":"en","type":"article","venue":"Molecules","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Glycomics Network; Österreichischen Akademie der Wissenschaften","keywords":"Cyclopentanes; Hydroxymethyl; Stereochemistry; Chemistry; Amine gas treating; Hexosaminidase; Propanoic acid; Biochemistry; Enzyme; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001307642,0.0004103645,0.0001953365,0.00009751834,0.00007569117,0.0001432287,0.0002361092,0.0001350711,0.001310895],"category_scores_gemma":[0.00008488613,0.0001109668,0.0001142088,0.00009185268,0.0001415085,0.0001451634,0.0001296772,0.00036979,0.0004440355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002576014,"about_ca_system_score_gemma":0.0002265797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00062187,"about_ca_topic_score_gemma":0.001153749,"domain_scores_codex":[0.9999342,0.00001131436,0.000005184703,0.00001165372,0.00001890395,0.00001872024],"domain_scores_gemma":[0.9999572,0.000007619466,0.000009793371,0.000003801398,0.00000559787,0.00001596933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002376998,0.00002685724,0.00004900832,0.00006201255,0.000004752485,0.0000524147,0.00001402725,0.0001924128,0.9964042,0.0002187834,0.00009690406,0.002640966],"study_design_scores_gemma":[0.00007406038,0.0004978411,0.0007444521,0.000004454867,0.00001002904,0.0001444443,0.000009458894,0.0003464694,0.9920144,0.00003166105,0.006116072,0.000006556316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762308,0.005397411,0.008032752,0.0001380803,0.00008338174,0.0002058352,0.0009573034,0.0002174507,0.008737078],"genre_scores_gemma":[0.9850269,0.003673622,0.005328613,0.00007687845,0.0000208544,0.0001101134,0.0007324325,0.00002706796,0.005003488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001310895,"threshold_uncertainty_score":0.004385352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316076215245445,"score_gpt":0.2314827980399759,"score_spread":0.2183220358875214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}