{"id":"W2792751283","doi":"10.1002/syn.22025","title":"Characterization of a 3xTg‐AD mouse model of Alzheimer's disease with the senescence accelerated mouse prone 8 (SAMP8) background","year":2018,"lang":"en","type":"article","venue":"Synapse","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Foundation for Innovation; Alzheimer Society","keywords":"Genetically modified mouse; Senescence; Glial fibrillary acidic protein; Neuropathology; NeuN; Transgene; Tauopathy; Alzheimer's disease; Biology; Ratón; Internal medicine; Neuroscience; Endocrinology; Neurodegeneration; Disease; Pathology; Chemistry; Medicine; Immunohistochemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001230963,0.0002104226,0.0003203227,0.0000941802,0.0001073195,0.00001834369,0.0001501082,0.00005794752,0.0001015157],"category_scores_gemma":[0.00002787135,0.0001261282,0.00007752601,0.000302448,0.000542575,0.0002088084,0.00006686174,0.0001077169,0.00003333148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003440438,"about_ca_system_score_gemma":0.0004992584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004391712,"about_ca_topic_score_gemma":0.0000129827,"domain_scores_codex":[0.9985012,0.00007911587,0.0002674292,0.0003089994,0.0005176475,0.0003255877],"domain_scores_gemma":[0.9982782,0.00002446726,0.0001942806,0.0006151686,0.0005423123,0.0003455908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009181835,0.00319267,0.01288821,0.0002969778,0.008478352,0.00005629062,0.0007540877,0.00004561621,0.9636769,0.0001972269,0.0001854143,0.001046398],"study_design_scores_gemma":[0.005656712,0.002033575,0.05890929,0.0002975151,0.002959586,0.00001070043,0.0002713402,0.02081337,0.9085592,0.00005361452,0.00002851993,0.0004065544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968795,0.0004154947,0.0005388004,0.0005744802,0.00001227991,0.001144765,0.0003027779,0.00004639529,0.00008550536],"genre_scores_gemma":[0.9988254,0.0001003052,0.0002338998,0.00009462603,0.00004379237,0.00008953028,0.0002942733,0.00004007632,0.0002781041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05511769,"threshold_uncertainty_score":0.514336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05523883433563741,"score_gpt":0.3073154461843404,"score_spread":0.252076611848703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}