{"id":"W2792795044","doi":"10.1016/j.jmb.2018.03.011","title":"Molecular Determinants for 23S rRNA Recognition and Modification by the E. coli Pseudouridine Synthase RluE","year":2018,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; Canada Foundation for Innovation","keywords":"Pseudouridine; 23S ribosomal RNA; RNA; Ribosomal RNA; Ribosome; Ribosome biogenesis; Biochemistry; Biology; 5.8S ribosomal RNA; Transfer RNA; Enzyme; Chemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001428477,0.0001688283,0.000225232,0.0001298726,0.0000869453,0.0002619592,0.0001770315,0.0003099033,0.000896818],"category_scores_gemma":[0.0003542381,0.0001285564,0.0002334804,0.00008148078,0.0001975469,0.0001334134,0.0001710686,0.0003061237,0.0005251114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001865675,"about_ca_system_score_gemma":0.0001502208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004311386,"about_ca_topic_score_gemma":0.0003844938,"domain_scores_codex":[0.999838,0.00004414873,0.000008940757,0.00001933577,0.00004622205,0.0000433443],"domain_scores_gemma":[0.9997506,0.00007937025,0.00005393629,0.00002327265,0.00003200787,0.00006069781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006592948,0.00001834964,0.0009237136,0.00001353727,0.000002873098,0.0001122502,0.00001205366,0.0001346223,0.9978078,0.0001321767,0.00001120677,0.0007656179],"study_design_scores_gemma":[0.000007431966,0.0002015781,0.01291613,0.000003754649,0.000006447841,0.0004560034,0.00006176898,0.001706129,0.9834351,0.00007296603,0.001125701,0.000007076336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971802,0.0004048345,0.001783331,0.00003638439,0.000005519951,0.00001088997,0.00003869248,0.00001852245,0.0005217431],"genre_scores_gemma":[0.9983426,0.00009180783,0.001039423,0.00001648397,0.000002350529,0.000004594157,0.0001110653,0.000005303236,0.0003863264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000896818,"threshold_uncertainty_score":0.00300014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02581388768682133,"score_gpt":0.312022438401193,"score_spread":0.2862085507143717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}