{"id":"W2792814802","doi":"10.1038/s41416-018-0012-2","title":"Comment on ‘Clinical significance of BRAF non-V600E mutations on the therapeutic effects of anti-EGFR monoclonal antibody treatment in patients with pretreated metastatic colorectal cancer: the Biomarker Research for anti-EGFR monoclonal Antibodies by Comprehensive Cancer genomics (BREAC) study’","year":2018,"lang":"en","type":"letter","venue":"British Journal of Cancer","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; McGill University; McGill University Health Centre","funders":"","keywords":"Monoclonal antibody; Colorectal cancer; Medicine; Cancer research; Oncology; Clinical significance; Antibody; Biomarker; Monoclonal; Cancer; Internal medicine; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00548625,0.0009519936,0.002294209,0.0009421401,0.002804371,0.003060449,0.002080702,0.05328984,0.005592947],"category_scores_gemma":[0.03588744,0.001117194,0.001619079,0.001208929,0.002608698,0.00266408,0.001406083,0.03527927,0.005901958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004189001,"about_ca_system_score_gemma":0.00522961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01016015,"about_ca_topic_score_gemma":0.01624604,"domain_scores_codex":[0.9947731,0.001479197,0.0008528042,0.0007968173,0.001249606,0.0008484965],"domain_scores_gemma":[0.9827653,0.01103384,0.001691838,0.0004921226,0.002127266,0.001889607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002072945,0.00003683994,0.001365881,0.0000773369,0.00003399633,0.000828058,0.0001037811,0.00005417899,0.0001427995,0.0009851472,0.9911116,0.005053087],"study_design_scores_gemma":[0.0006456582,0.0003182237,0.007215488,0.0006515605,0.0002044638,0.001499718,0.0004982831,0.0006072528,0.0005949324,0.006450926,0.9811095,0.000204066],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0007041479,0.0009808558,0.00006035482,0.9724946,0.02363532,0.00001682763,0.0003467468,0.00003648141,0.001724601],"genre_scores_gemma":[0.00265193,0.0005794406,0.0001190627,0.9583086,0.0347512,0.00004868926,0.00009433792,0.00001791438,0.003428895],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.05328984,"threshold_uncertainty_score":0.03039348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07379705001419633,"score_gpt":0.4074493872111625,"score_spread":0.3336523371969661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}