{"id":"W2792835688","doi":"10.1016/j.jmb.2018.02.019","title":"Biophysical Analysis of Bacterial CTP Synthase Filaments Formed in the Presence of the Chemotherapeutic Metabolite Gemcitabine-5′-triphosphate","year":2018,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Nova Scotia Health Research Foundation; Terry Fox Research Institute; Canadian Imperial Bank of Commerce; Beatrice Hunter Cancer Research Institute","keywords":"Protein filament; Biochemistry; Chemistry; Enzyme; Cytosol; Cytidine; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006512869,0.0001579118,0.0004311247,0.0001546574,0.00003310548,0.00001015289,0.0008834973,0.000188773,0.00003252952],"category_scores_gemma":[0.0003675156,0.00008800931,0.0005108124,0.0007271452,0.0006220153,0.000005190645,0.0002035462,0.000197499,7.098445e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001092208,"about_ca_system_score_gemma":0.0001207465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002458488,"about_ca_topic_score_gemma":0.00001109014,"domain_scores_codex":[0.9982116,0.0004160879,0.0005783418,0.0002189476,0.0002880578,0.0002869961],"domain_scores_gemma":[0.9986108,0.00005029074,0.0004568446,0.0005022403,0.0003209689,0.00005887226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004753399,0.0002055385,0.00138497,0.00001525569,0.0007321449,0.000003713809,0.00007363966,0.000007911101,0.9958268,0.0002422233,0.00005368234,0.0009788218],"study_design_scores_gemma":[0.0008122899,0.0006069638,0.006433642,0.0000155259,0.0003559295,0.00001551111,0.00003568498,0.00005972123,0.9896825,0.0002805991,0.001609686,0.00009196772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966014,0.0009846849,0.001595329,0.00037724,0.0001394331,0.0001804401,0.00003650151,8.603407e-7,0.00008412334],"genre_scores_gemma":[0.999068,0.0001182334,0.0003072396,0.0003283333,0.0001186103,0.000005491544,0.0000236774,0.00001092175,0.0000195238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006144281,"threshold_uncertainty_score":0.3588915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01104033081295705,"score_gpt":0.3051966252584177,"score_spread":0.2941562944454607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}