{"id":"W2792843706","doi":"10.1016/j.neuron.2018.04.021","title":"A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action","year":2018,"lang":"en","type":"article","venue":"Neuron","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":299,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; University of California, San Francisco; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institute on Drug Abuse; M.S.I. Foundation","keywords":"Internalization; Endosome; Golgi apparatus; Receptor; Neuroscience; Neuromodulation; Opioid peptide; Biology; Cell biology; Chemistry; Opioid; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001228055,0.00008431994,0.00008765912,0.00003023597,0.000041667,0.00001023118,0.00009102628,0.0000761962,0.00005847932],"category_scores_gemma":[0.00008582098,0.00007901097,0.00004375447,0.00007587281,0.00004891883,0.000002356805,0.00003353888,0.00003957472,0.00001931947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004972349,"about_ca_system_score_gemma":0.00003195732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001362958,"about_ca_topic_score_gemma":0.000009351207,"domain_scores_codex":[0.9993088,0.00006294413,0.0001790853,0.0002222389,0.0001037469,0.0001232044],"domain_scores_gemma":[0.9994912,0.00000836688,0.00009109236,0.0002183807,0.0001486407,0.00004229561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004836423,0.00002377502,0.0001727093,0.00001510813,0.000006180237,2.629687e-7,0.00003708462,0.0000138826,0.995068,0.00007740916,0.0006842031,0.003852983],"study_design_scores_gemma":[0.000160709,0.0003818362,0.001133787,0.00001222814,0.000008321507,0.000003486426,0.00002135975,0.0001658871,0.9900362,0.0001060783,0.007892062,0.0000779906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952843,0.00009880911,0.003661959,0.0000659553,0.00029637,0.0001148666,0.000003503383,0.00000964252,0.0004645692],"genre_scores_gemma":[0.9973204,0.0001052852,0.00150772,0.0002115371,0.0003253158,0.000005142957,0.00002012036,0.00001518302,0.0004892724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007207858,"threshold_uncertainty_score":0.3221974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02861079876682013,"score_gpt":0.2747069183605019,"score_spread":0.2460961195936817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}