{"id":"W2792843706","doi":"10.1016/j.neuron.2018.04.021","title":"A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action","year":2018,"lang":"en","type":"article","venue":"Neuron","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":299,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; University of California, San Francisco; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institute on Drug Abuse; M.S.I. Foundation","keywords":"Internalization; Endosome; Golgi apparatus; Receptor; Neuroscience; Neuromodulation; Opioid peptide; Biology; Cell biology; Chemistry; Opioid; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002902032,0.0003057072,0.0003243629,0.0002306303,0.0002340704,0.0006148038,0.0008813873,0.0007905316,0.001105359],"category_scores_gemma":[0.0004927847,0.0003217309,0.0002430156,0.000198787,0.0005941551,0.0004496417,0.0004391599,0.001010652,0.0004714833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000895721,"about_ca_system_score_gemma":0.0004173277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008061093,"about_ca_topic_score_gemma":0.001576545,"domain_scores_codex":[0.9997752,0.00002273686,0.00001052664,0.0000682598,0.00007366404,0.00004962862],"domain_scores_gemma":[0.9997372,0.00009563559,0.00005609835,0.00003015386,0.00002930967,0.00005150693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002689196,0.000008148329,0.00003826922,0.0000059188,0.000001119396,0.00001463427,0.000004076363,0.00002985297,0.9990293,0.0002886663,0.00001827113,0.0005349406],"study_design_scores_gemma":[0.000008726928,0.0000422269,0.0004904583,0.000001888258,0.00000524293,0.0001096779,0.000009573821,0.001861292,0.9968706,0.0001284367,0.0004666228,0.000005437562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9653561,0.0006058747,0.0300022,0.0007038431,0.0001433099,0.00003078409,0.0002908466,0.0002579541,0.002609206],"genre_scores_gemma":[0.9783236,0.0003974221,0.01691719,0.0001575768,0.00002005727,0.00002158422,0.0001860956,0.0000776197,0.003898924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001105359,"threshold_uncertainty_score":0.006498933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02861079876682013,"score_gpt":0.2747069183605019,"score_spread":0.2460961195936817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}