{"id":"W2792862146","doi":"10.1158/1535-7163.mct-17-0559","title":"Anti-<i>hTERT</i> siRNA-Loaded Nanoparticles Block the Growth of Anaplastic Thyroid Cancer Xenograft","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Association for the Study of the Liver","keywords":"Anaplastic thyroid cancer; Telomerase; Telomerase reverse transcriptase; Thyroid cancer; Chemistry; Cancer research; In vivo; Pharmacology; Cancer cell; Cytotoxicity; Poloxamer; Cancer; In vitro; Molecular biology; Medicine; Biology; Biochemistry; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001059741,0.0003169336,0.0004698778,0.00007771159,0.0001558055,0.00003336263,0.0002521676,0.0001039625,0.000137284],"category_scores_gemma":[0.00001034391,0.0002090616,0.0002181015,0.0004875111,0.0004492421,0.0000471969,0.00006611532,0.0001776149,0.00001799192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001622926,"about_ca_system_score_gemma":0.0002603861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005957595,"about_ca_topic_score_gemma":0.0002324983,"domain_scores_codex":[0.9981652,0.00008000997,0.0003893771,0.0003912802,0.000490532,0.0004836346],"domain_scores_gemma":[0.9986776,0.00006440889,0.0001956581,0.0005833009,0.0003419404,0.000137131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004017231,0.0004676901,0.02673698,0.00009580732,0.001444362,0.00004637604,0.0008934345,0.00006192331,0.9616091,0.0004485741,0.0008599459,0.006934115],"study_design_scores_gemma":[0.00234979,0.001073139,0.02240642,0.000218528,0.001234561,0.00002083193,0.00007766131,0.0001457815,0.9633388,0.0001711595,0.008725829,0.0002375386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638576,0.02756882,0.0001086389,0.007055292,0.0004121337,0.0005602728,0.00006075744,0.00006183892,0.0003146741],"genre_scores_gemma":[0.9893267,0.00372149,0.0001254115,0.006141425,0.0002894717,0.0002303549,0.000005598249,0.00006711361,0.00009243468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02546913,"threshold_uncertainty_score":0.8525283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02168774687493087,"score_gpt":0.2887609737655415,"score_spread":0.2670732268906106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}