{"id":"W2792862146","doi":"10.1158/1535-7163.mct-17-0559","title":"Anti-<i>hTERT</i> siRNA-Loaded Nanoparticles Block the Growth of Anaplastic Thyroid Cancer Xenograft","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Association for the Study of the Liver","keywords":"Anaplastic thyroid cancer; Telomerase; Telomerase reverse transcriptase; Thyroid cancer; Chemistry; Cancer research; In vivo; Pharmacology; Cancer cell; Cytotoxicity; Poloxamer; Cancer; In vitro; Molecular biology; Medicine; Biology; Biochemistry; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001148502,0.0003105196,0.0002480257,0.0001551177,0.00009145719,0.0001557109,0.0001688547,0.0002611881,0.0007543456],"category_scores_gemma":[0.0000636471,0.0001072769,0.0002121093,0.00008781345,0.0001261873,0.000134775,0.00008028422,0.000401584,0.0002301681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002392197,"about_ca_system_score_gemma":0.0001749824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001410972,"about_ca_topic_score_gemma":0.002126365,"domain_scores_codex":[0.9999058,0.00001022778,0.000007857969,0.00002183094,0.00003326136,0.00002095844],"domain_scores_gemma":[0.9999341,0.00001439404,0.00001852871,0.000007476823,0.00001176799,0.00001380673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003140029,0.00002106729,0.00002527361,0.00001324909,0.000002434291,0.000009900507,0.000005521988,0.00004423364,0.9992249,0.00002271043,0.00002533336,0.0005740348],"study_design_scores_gemma":[0.000008657492,0.0003923588,0.0007047213,0.000001900454,0.00001162638,0.00004056944,0.000005161166,0.0008265479,0.9971812,0.000007181407,0.0008185297,0.000001640867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931937,0.001169448,0.003345923,0.00006293189,0.00003849801,0.00004451267,0.0001993508,0.0001933148,0.001752343],"genre_scores_gemma":[0.9917369,0.0005684278,0.003203016,0.00003891015,0.00001210086,0.00004991276,0.000309008,0.00003002511,0.004051808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001410972,"threshold_uncertainty_score":0.002805471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02168774687493087,"score_gpt":0.2887609737655415,"score_spread":0.2670732268906106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}