{"id":"W2792880182","doi":"10.1093/jcag/gwy009.164","title":"A164 HIGHLY EFFICIENT DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS INTO LONG-TERM EXPANDABLE “MINI-GUT” ORGANOIDS","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stemcell Technologies","funders":"","keywords":"Organoid; Endoderm; Induced pluripotent stem cell; Cell biology; Stem cell; Biology; Hindgut; Embryonic stem cell; Cellular differentiation; KLF4; Directed differentiation; Mesenchyme; SOX2; Matrigel; CDX2; Adult stem cell; Mesenchymal stem cell; Cell culture; Homeobox; Biochemistry; Genetics; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002227895,0.0003320349,0.0001694911,0.0002081604,0.000133797,0.0002583764,0.0002035094,0.0002169551,0.002186986],"category_scores_gemma":[0.0001259885,0.0001721274,0.0002309042,0.0001404616,0.0001379048,0.0002221351,0.0002831311,0.0004549678,0.001338832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001090661,"about_ca_system_score_gemma":0.0001896376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002818161,"about_ca_topic_score_gemma":0.000608983,"domain_scores_codex":[0.9998517,0.00001298252,0.00002732285,0.0000332569,0.00005656498,0.00001815909],"domain_scores_gemma":[0.999918,0.00001564417,0.00001523875,0.00001539399,0.00001604934,0.00001964187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001754476,0.000008669523,0.00009577018,0.00003281042,0.000001724852,0.0000358981,0.00001548679,0.00004664854,0.9973485,0.00008018643,0.0001302549,0.002186425],"study_design_scores_gemma":[0.000006967414,0.0001227195,0.002349818,0.00001035519,0.00001098279,0.0003222851,0.00001292633,0.000644611,0.9839833,0.00003435023,0.01249604,0.000005685689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8280423,0.004803624,0.142891,0.0003726153,0.0002912866,0.0006964118,0.007532927,0.002043979,0.0133258],"genre_scores_gemma":[0.8608507,0.003419798,0.1033268,0.0001970785,0.00004000663,0.0009038735,0.009768232,0.0002176381,0.02127599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002186986,"threshold_uncertainty_score":0.007316172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007959601231881875,"score_gpt":0.2358820045153246,"score_spread":0.2279224032834427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}