{"id":"W2792910868","doi":"10.1016/j.devcel.2018.02.001","title":"Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase","year":2018,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institutes of Health; Astellas Foundation for Research on Metabolic Disorders; Japan Society for the Promotion of Science; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Cystic Fibrosis Canada; National Institute of Diabetes and Digestive and Kidney Diseases; Mitsubishi Foundation; Canadian Institutes of Health Research; Uehara Memorial Foundation; Sumitomo Foundation","keywords":"Biology; Ubiquitin ligase; Chaperone (clinical); Cell biology; DNA ligase; Genetics; Ubiquitin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003732656,0.000182787,0.0003749696,0.00006520309,0.00009115462,0.0000166179,0.0001621079,0.0000738712,0.00174652],"category_scores_gemma":[0.0001459223,0.0001587794,0.00007452264,0.0001516015,0.0003000355,0.0001053109,0.00009147986,0.0001657732,0.0002528385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002666807,"about_ca_system_score_gemma":0.0002654665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000134893,"about_ca_topic_score_gemma":0.00003648873,"domain_scores_codex":[0.9979903,0.00006339069,0.0004528274,0.0003372397,0.0007313636,0.0004248761],"domain_scores_gemma":[0.9991415,0.00009311855,0.000111755,0.0002077276,0.0001697579,0.0002761486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009775135,0.0004001237,0.01760817,0.0001700672,0.00005608081,0.00002096294,0.0007087702,2.871225e-7,0.9701967,0.00003677163,0.004959015,0.004865602],"study_design_scores_gemma":[0.005196061,0.0007668887,0.05858653,0.00007876748,0.00001957883,0.00003628201,0.000865604,0.00007830819,0.8991854,0.00003659401,0.03490531,0.0002446996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834,0.0004947813,0.001020245,0.0002451795,0.000150443,0.0004855618,0.00008038301,0.00004377833,0.01407959],"genre_scores_gemma":[0.9885405,0.00002468908,0.006783729,0.0003872717,0.00009142554,0.00002868983,0.00006278801,0.00002397979,0.004056979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07101126,"threshold_uncertainty_score":0.999166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01550408475584064,"score_gpt":0.307377204206109,"score_spread":0.2918731194502684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}