{"id":"W2792945963","doi":"10.1016/j.coi.2018.03.003","title":"Immune signatures predicting responses to immunomodulatory antibody therapy","year":2018,"lang":"en","type":"review","venue":"Current Opinion in Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences North","funders":"Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; European Commission","keywords":"Medicine; Melanoma; Antibody therapy; Cancer; Cancer therapy; Antibody; Immune system; Immunology; Immunotherapy; Intensive care medicine; Monoclonal antibody; Internal medicine; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.001802323,0.00167179,0.004045594,0.002747619,0.0005997433,0.0001006049,0.002447288,0.002290008,0.0009237897],"category_scores_gemma":[0.000768786,0.001452788,0.001273919,0.001488845,0.001027138,0.0002751359,0.0008391312,0.003253635,0.003395901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004615897,"about_ca_system_score_gemma":0.0011747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009911017,"about_ca_topic_score_gemma":0.000001676435,"domain_scores_codex":[0.9890162,0.004391716,0.002908129,0.001692673,0.0001573105,0.00183392],"domain_scores_gemma":[0.9945412,0.001684804,0.001223145,0.002245092,0.0002471282,0.00005860358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002630498,0.0007593174,0.00007860177,0.002564793,0.001658914,0.000004883313,0.0008629207,7.991563e-7,0.007094459,0.0002801136,0.003178002,0.9808867],"study_design_scores_gemma":[0.002180309,0.001233199,0.001186776,0.02023621,0.00009249632,0.0002294881,0.00009454515,3.494566e-7,0.0004066265,0.00003408945,0.9729658,0.001340119],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001801533,0.9523404,0.000047154,0.00004712337,0.0424518,0.002666149,0.0002191122,0.000335881,0.00009090904],"genre_scores_gemma":[0.0003001174,0.9952253,0.00003760783,0.00003706261,0.0005328949,0.0007937632,0.001783823,0.0002590269,0.00103044],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9795466,"threshold_uncertainty_score":0.9999895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0677865475957538,"score_gpt":0.3887656890210985,"score_spread":0.3209791414253447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}