{"id":"W2793031031","doi":"10.1158/1078-0432.ccr-18-1740","title":"USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; National Cancer Institute; National Institutes of Health; Associazione Italiana per la Ricerca sul Cancro; York University; European Hematology Association; Northwestern University","keywords":"Demethylase; Deubiquitinating enzyme; Biology; Cancer research; Leukemia; Chromatin; Druggability; Cell growth; Transcription factor; Epigenetics; Gene; Ubiquitin; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00165398,0.000116999,0.0001500433,0.00004353838,0.0001648386,0.00005343308,0.0004449063,0.0001665482,0.0002206946],"category_scores_gemma":[0.000190858,0.00007445305,0.00006980749,0.0003712052,0.000702079,0.000003534394,0.0001339487,0.0005123498,0.0001267133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006444247,"about_ca_system_score_gemma":0.001041275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002601365,"about_ca_topic_score_gemma":0.00293144,"domain_scores_codex":[0.9979994,0.0004046867,0.000279491,0.0004909707,0.0003454363,0.0004799843],"domain_scores_gemma":[0.9988599,0.0001082349,0.00002783186,0.0003698108,0.0004483587,0.000185878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006868291,0.001025112,0.05071211,0.00008452322,0.0001448488,0.00003201513,0.0008441152,0.00009701305,0.7471133,0.0004683525,0.02850017,0.1641101],"study_design_scores_gemma":[0.002130433,0.007585853,0.01637363,0.00007749349,0.00001068669,0.000004636649,0.0002081257,0.0001460785,0.3825373,0.000102627,0.590538,0.0002851576],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932462,0.0006512328,0.00007183442,0.001517019,0.0001121289,0.0009837246,0.00002911357,0.00001127325,0.003377493],"genre_scores_gemma":[0.9946462,0.0003394121,0.0005426735,0.0009425481,0.001085473,0.0007508041,0.00002411015,0.00002363167,0.001645163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5620378,"threshold_uncertainty_score":0.3036107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1262555437642063,"score_gpt":0.4681404210928666,"score_spread":0.3418848773286604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}