{"id":"W2793038282","doi":"10.1124/mol.117.110908","title":"Inhibition of CD45 Phosphatase Activity Induces Cell Cycle Arrest and Apoptosis of CD45+ Lymphoid Tumors Ex Vivo and In Vivo","year":2018,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Programmed cell death; Apoptosis; Protein tyrosine phosphatase; Cancer research; Cell cycle; Biology; Cell growth; In vivo; Cell biology; Ex vivo; Kinase; Molecular biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002455286,0.0002281436,0.0003193933,0.0001152678,0.00004514994,0.000008833605,0.0001387693,0.00017861,0.00006882401],"category_scores_gemma":[0.0000583126,0.0002498977,0.00005177964,0.0001756209,0.0005457429,0.00001657943,0.0002966429,0.00009695081,0.000001628132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002212799,"about_ca_system_score_gemma":0.0001008112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002571395,"about_ca_topic_score_gemma":0.00003221242,"domain_scores_codex":[0.9985765,0.000168015,0.0003086814,0.0004760273,0.0001246319,0.0003461564],"domain_scores_gemma":[0.9992817,0.00002654807,0.0002397,0.0002370312,0.00008978559,0.0001252015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005002382,0.0002632594,0.0008546439,0.0001156856,0.00004042218,0.00001713252,0.0000555984,0.00001646519,0.9969833,0.00004397373,0.00055157,0.0005577499],"study_design_scores_gemma":[0.002096968,0.0005414888,0.0005634786,0.00002953547,0.00005519395,0.00001485476,0.00002506472,0.00007843739,0.9959567,0.00008503268,0.0003332329,0.000220056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935542,0.00523006,0.0001970696,0.00007298603,0.0001377307,0.0003894957,0.0002332778,0.000008372794,0.0001767612],"genre_scores_gemma":[0.9988061,0.0003956376,0.0003215084,0.0002797715,0.00007209062,0.00004384686,0.00004132197,0.00002687338,0.00001280903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005251895,"threshold_uncertainty_score":0.9999954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006319490177551973,"score_gpt":0.2531244136730879,"score_spread":0.2468049234955359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}