{"id":"W2793047804","doi":"10.3390/metabo8010020","title":"Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX","year":2018,"lang":"en","type":"review","venue":"Metabolites","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Occupational Cancer Research Centre","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Tumor microenvironment; Cancer cell; Tumor hypoxia; Hypoxia (environmental); Biology; Transporter; Interactome; Biochemistry; Chemistry; Cancer; Cell biology; Cancer research; Tumor cells; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000344298,0.0006292339,0.000783182,0.001308019,0.0002443774,0.0008233022,0.0006042108,0.0007979905,0.002809688],"category_scores_gemma":[0.0004385511,0.0002427956,0.0003564984,0.001243277,0.0002592111,0.0009339076,0.0005404215,0.00141211,0.001919633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006311827,"about_ca_system_score_gemma":0.0009287198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029009,"about_ca_topic_score_gemma":0.002026438,"domain_scores_codex":[0.9998995,0.00001274229,0.00001667795,0.00002199049,0.00003576659,0.00001330495],"domain_scores_gemma":[0.9998524,0.00004869257,0.00002507732,0.000004867997,0.00005143658,0.00001742364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009384802,0.00005236512,0.0001997722,0.01473157,0.00009129678,0.0002229121,0.00005555276,0.0004014726,0.003237264,0.005437719,0.03626693,0.9392093],"study_design_scores_gemma":[0.00001250111,0.00005486255,0.0006332272,0.001382412,0.00006637717,0.0006060642,0.00002770981,0.00009852194,0.0006985858,0.001170341,0.9952382,0.00001122143],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001923469,0.9976732,0.000169877,0.0004465265,0.0002410976,0.000004916482,0.00003072309,0.00001173995,0.001229597],"genre_scores_gemma":[0.0007306624,0.9978338,0.0001893911,0.0001701344,0.0001271489,0.000006824009,0.00003712201,0.000001904409,0.0009030521],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002809688,"threshold_uncertainty_score":0.009399295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01523151297560633,"score_gpt":0.2603126602032459,"score_spread":0.2450811472276396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}