{"id":"W2793061384","doi":"10.1093/ecco-jcc/jjx180.063","title":"DOP026 Efficacy and safety of dose escalation to tofacitinib 10 mg BID for patients with ulcerative colitis following loss of response on tofacitinib 5 mg BID maintenance therapy: results from OCTAVE open","year":2018,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Tofacitinib; Medicine; Octave (electronics); Ulcerative colitis; Maintenance therapy; Internal medicine; Surgery; Gastroenterology; Chemotherapy; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001615675,0.0003618809,0.001406905,0.0003684535,0.0002214054,0.001014663,0.0003890395,0.0006462779,0.00171384],"category_scores_gemma":[0.001967195,0.0002409287,0.001551024,0.0003424643,0.0003331647,0.0008209939,0.0003445305,0.001569115,0.0003800347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005306479,"about_ca_system_score_gemma":0.00057448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003165401,"about_ca_topic_score_gemma":0.001419144,"domain_scores_codex":[0.9992515,0.0003084484,0.00008358147,0.0001124831,0.0001486362,0.00009524835],"domain_scores_gemma":[0.9985191,0.0004100697,0.0003847415,0.0001331485,0.0001458724,0.0004071287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4424674,0.01732507,0.0622834,0.001534448,0.0029197,0.0004089963,0.000363058,0.003571099,0.06803566,0.0003384691,0.003923905,0.3968287],"study_design_scores_gemma":[0.1605151,0.5720615,0.229348,0.0002728624,0.00304927,0.001905288,0.0003670109,0.006917706,0.0131245,0.0007909387,0.0114881,0.0001596347],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932606,0.002593256,0.0002939121,0.0002399708,0.00004039668,0.0003548579,0.0009732249,0.00003671354,0.002207059],"genre_scores_gemma":[0.994266,0.0009325079,0.0007901886,0.0005402109,0.0000679842,0.0002630281,0.002309266,0.00001139844,0.0008194132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00171384,"threshold_uncertainty_score":0.008544624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01118702274447444,"score_gpt":0.269799288386146,"score_spread":0.2586122656416716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}