{"id":"W2793126529","doi":"10.1158/2159-8290.cd-17-1327","title":"Genetic Mechanisms of Immune Evasion in Colorectal Cancer","year":2018,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":550,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Ontario Institute for Cancer Research","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; U.S. National Library of Medicine; Ontario Ministry of Research and Innovation; Stand Up To Cancer; Dana-Farber/Harvard Cancer Center; Gary Bennett Family Fund; Parker Institute for Cancer Immunotherapy; American Association for Cancer Research; American Society of Clinical Oncology; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Hope Foundation; National Institutes of Health; Conquer Cancer Foundation; Tower Cancer Research Foundation","keywords":"Evasion (ethics); Immune system; Colorectal cancer; Cancer; Biology; Computational biology; Immunology; Cancer research; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001124578,0.000133596,0.0003007251,0.0001082785,0.00003198554,0.00001088482,0.00009664975,0.0000852607,0.0007596885],"category_scores_gemma":[0.00001053378,0.0001106859,0.0001219616,0.0003226417,0.0001903535,0.0001139694,0.00003529813,0.00009260677,0.000005909981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002945385,"about_ca_system_score_gemma":0.0004031087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003692652,"about_ca_topic_score_gemma":0.001490211,"domain_scores_codex":[0.9989694,0.00002361974,0.0003339058,0.000235743,0.0002072857,0.0002300978],"domain_scores_gemma":[0.9995629,0.00001827078,0.0001186252,0.0001875333,0.00007118152,0.00004144992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003293094,0.0000979074,0.02165771,0.000103521,0.0001109193,0.000009063815,0.0004042411,0.000009045723,0.9568343,0.00007911119,0.0003722165,0.01702893],"study_design_scores_gemma":[0.00230441,0.0004540741,0.4176449,0.0005307346,0.00005432037,0.000007566363,0.0001390354,0.00008125538,0.5778681,0.0002241629,0.0005647672,0.0001266958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99102,0.006281067,0.0003412735,0.0003390225,0.0008678671,0.0003410422,0.00004451312,0.00001603989,0.0007492144],"genre_scores_gemma":[0.9962057,0.002327527,0.0001519131,0.0004042847,0.0002541841,0.0001106942,0.000005383457,0.00002343825,0.0005168456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3959871,"threshold_uncertainty_score":0.8318056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418535128695848,"score_gpt":0.2869981973630584,"score_spread":0.2728128460761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}