{"id":"W2793126529","doi":"10.1158/2159-8290.cd-17-1327","title":"Genetic Mechanisms of Immune Evasion in Colorectal Cancer","year":2018,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":550,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Ontario Institute for Cancer Research","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; U.S. National Library of Medicine; Ontario Ministry of Research and Innovation; Stand Up To Cancer; Dana-Farber/Harvard Cancer Center; Gary Bennett Family Fund; Parker Institute for Cancer Immunotherapy; American Association for Cancer Research; American Society of Clinical Oncology; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Hope Foundation; National Institutes of Health; Conquer Cancer Foundation; Tower Cancer Research Foundation","keywords":"Evasion (ethics); Immune system; Colorectal cancer; Cancer; Biology; Computational biology; Immunology; Cancer research; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000179853,0.0001337901,0.0001926231,0.0009109904,0.0001438057,0.0002935838,0.0001440241,0.0001654807,0.001366403],"category_scores_gemma":[0.0002414848,0.00008070693,0.0001429824,0.000741771,0.0001723775,0.00009106923,0.0001888378,0.0001422631,0.0002006011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003714408,"about_ca_system_score_gemma":0.0001542254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008274293,"about_ca_topic_score_gemma":0.001356383,"domain_scores_codex":[0.9998419,0.00002611498,0.000009820672,0.00003744347,0.00004544845,0.00003927178],"domain_scores_gemma":[0.9998007,0.00003289267,0.0001051473,0.00001701517,0.00001828048,0.00002599777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009620008,0.00008590712,0.5540988,0.0002913685,0.0001857164,0.001438432,0.0001755643,0.0009714728,0.3908355,0.001196888,0.0007587255,0.04899971],"study_design_scores_gemma":[0.00001803551,0.000147913,0.9624138,0.00001642312,0.00005171453,0.003053942,0.0001275319,0.0009490487,0.02899638,0.0004278334,0.003789658,0.000007621436],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950042,0.002496131,0.0007180548,0.00006272408,0.000004484661,0.00001265218,0.000578833,0.00003194894,0.001090895],"genre_scores_gemma":[0.9984469,0.0003907371,0.0004194705,0.00002234832,0.000005007649,0.000006791392,0.0003774979,0.000004009945,0.0003273134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001366403,"threshold_uncertainty_score":0.00457108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418535128695848,"score_gpt":0.2869981973630584,"score_spread":0.2728128460761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}