{"id":"W2793162026","doi":"10.1177/2472555218766278","title":"Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain","year":2018,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Innovative Medicines Initiative; European Federation of Pharmaceutical Industries and Associations; Novartis Pharma; Genome Canada","keywords":"PHD finger; Small molecule; Histone; Histone H3; Epigenetics; Methyltransferase; DNA; DNA methylation; Biology; Function (biology); Chemistry; Cell biology; Computational biology; Methylation; Biochemistry; Zinc finger; Transcription factor; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002416685,0.0001545291,0.0001893,0.00005033437,0.0000881282,0.00003965855,0.0003096231,0.0001135498,0.000005847548],"category_scores_gemma":[0.0001168441,0.0001164896,0.0001646365,0.0002083256,0.0002057492,0.0000114535,0.0002792415,0.00005828055,0.000005025056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001761445,"about_ca_system_score_gemma":0.000119591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004068177,"about_ca_topic_score_gemma":0.0001683426,"domain_scores_codex":[0.9988688,0.00007938187,0.000320862,0.0003104214,0.0001932811,0.0002272677],"domain_scores_gemma":[0.9991174,0.00002046345,0.0001859108,0.0005402667,0.00009239399,0.00004355365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006682071,0.00006091077,0.02092843,0.00002083296,0.00004582937,4.783669e-7,0.0001022814,0.00002013648,0.9777418,0.0006698574,0.0001769237,0.0001657501],"study_design_scores_gemma":[0.0002911806,0.0003753251,0.01710199,0.00004429519,0.00002170067,0.000001007046,0.0001076983,0.000006647338,0.9798236,0.0004747679,0.001604243,0.0001475597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885089,0.0003365897,0.008483465,0.0001072356,0.0003701919,0.0002341517,0.00008511455,0.000003806054,0.001870518],"genre_scores_gemma":[0.9977864,0.0000588122,0.000645528,0.00008332505,0.000232703,0.000009057769,0.00003406248,0.00002388523,0.001126201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009277497,"threshold_uncertainty_score":0.4750308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01132458514239882,"score_gpt":0.2569214421486916,"score_spread":0.2455968570062927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}