{"id":"W2793162026","doi":"10.1177/2472555218766278","title":"Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain","year":2018,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Innovative Medicines Initiative; European Federation of Pharmaceutical Industries and Associations; Novartis Pharma; Genome Canada","keywords":"PHD finger; Small molecule; Histone; Histone H3; Epigenetics; Methyltransferase; DNA; DNA methylation; Biology; Function (biology); Chemistry; Cell biology; Computational biology; Methylation; Biochemistry; Zinc finger; Transcription factor; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002074303,0.0005486641,0.0005747193,0.0003129361,0.0001497424,0.00034503,0.0005320373,0.0003905637,0.001024526],"category_scores_gemma":[0.0002023026,0.0002507704,0.000420451,0.0002202002,0.0001755493,0.0001990863,0.0002355323,0.0008745419,0.0003709598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004086089,"about_ca_system_score_gemma":0.0002781725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007120316,"about_ca_topic_score_gemma":0.002704976,"domain_scores_codex":[0.9999156,0.00001339653,0.000004726724,0.00001641931,0.00002178569,0.00002801935],"domain_scores_gemma":[0.9999303,0.00001629389,0.00001581348,0.000004400901,0.00001218449,0.00002097827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006008052,0.000734851,0.0006085224,0.0003500873,0.000130102,0.0003817483,0.00006709152,0.002509304,0.9587149,0.001130742,0.001665912,0.03310597],"study_design_scores_gemma":[0.002440714,0.01749558,0.009061215,0.0001169258,0.0004439999,0.001620446,0.0001417475,0.01380662,0.9117047,0.0007715677,0.04229201,0.0001046126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.958283,0.01638976,0.01232712,0.0005587836,0.0002082301,0.0008163352,0.00181206,0.0004740708,0.009130679],"genre_scores_gemma":[0.9689142,0.01222796,0.007348232,0.0006472638,0.00004519209,0.0004752909,0.00248888,0.00003549283,0.007817479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001024526,"threshold_uncertainty_score":0.003427327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01132458514239882,"score_gpt":0.2569214421486916,"score_spread":0.2455968570062927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}