{"id":"W2793166195","doi":"10.1186/s13227-018-0092-3","title":"Developmental constraint through negative pleiotropy in the zygomatic arch","year":2018,"lang":"en","type":"article","venue":"EvoDevo","topic":"Morphological variations and asymmetry","field":"Mathematics","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; Alberta Bone and Joint Health Institute; University of Calgary","funders":"National Institute of Dental and Craniofacial Research; National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institute of Diabetes and Digestive and Kidney Diseases; University of Calgary; Alberta Innovates; National Institute of Environmental Health Sciences; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Alberta Innovates - Health Solutions; National Institutes of Health; March of Dimes Foundation","keywords":"Biology; Pleiotropy; Skull; Population; Zygomatic bone; Zygomatic arch; Anatomy; Evolutionary biology; Quantitative trait locus; Genetics; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004191148,0.0001161555,0.0001579147,0.00003785002,0.0001361913,0.00003344001,0.000247835,0.00005950714,0.001006754],"category_scores_gemma":[0.0005931407,0.00006966973,0.00004066135,0.0002955943,0.0002145488,0.00007464068,0.00006028058,0.0001712264,0.0002297219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005681417,"about_ca_system_score_gemma":0.00005586227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000597006,"about_ca_topic_score_gemma":0.00007506989,"domain_scores_codex":[0.9989616,0.0001443077,0.000277402,0.0001726371,0.0002136309,0.0002304474],"domain_scores_gemma":[0.9989283,0.0007842361,0.00007104064,0.000151548,0.00004080352,0.00002404772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00001843092,0.0003810077,0.004485552,0.00003119957,0.0000437759,0.0000379032,0.01313697,6.102283e-7,0.0009679219,0.9593795,0.01962653,0.001890614],"study_design_scores_gemma":[0.001497474,0.0002754075,0.07640179,0.0001277441,0.0000309734,0.0001575122,0.0110195,0.0007738184,0.00342741,0.8989592,0.00684531,0.0004838193],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.864171,0.00001576894,0.03076427,0.00105162,0.00009602908,0.0004393561,0.00001194442,0.00005227188,0.1033978],"genre_scores_gemma":[0.8159506,0.000001858489,0.1831519,0.0006020769,0.00008787357,0.00003258927,0.000002315031,0.000007281682,0.0001635191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1523876,"threshold_uncertainty_score":0.9999065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08906985923699004,"score_gpt":0.3415572997113808,"score_spread":0.2524874404743908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}