{"id":"W2793168140","doi":"10.1073/pnas.1716452115","title":"Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; Intellectual and Developmental Disabilities Research Center; National Cancer Institute; Government of Canada; National Institute of Allergy and Infectious Diseases; Parkinson's Foundation; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute","keywords":"Cancer research; Biology; Lymphoma; Suppressor; Haematopoiesis; KRAS; Leukemia; Neuroblastoma RAS viral oncogene homolog; T cell; Immunology; Mutation; Cancer; Genetics; Stem cell; Gene; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001746775,0.0009740508,0.000352875,0.002128699,0.0004252106,0.0006527574,0.0004441327,0.0009359359,0.004772563],"category_scores_gemma":[0.0002336452,0.0004890556,0.0003848049,0.0006411114,0.0006757633,0.00023335,0.0004739232,0.001007859,0.001069592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006610189,"about_ca_system_score_gemma":0.0002998346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009268717,"about_ca_topic_score_gemma":0.001734696,"domain_scores_codex":[0.9996104,0.00006622481,0.00003967902,0.0001004179,0.00009247996,0.00009081803],"domain_scores_gemma":[0.9994184,0.00007510022,0.0002241538,0.00003663592,0.00001786684,0.0002279807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002882609,0.00009743788,0.001031222,0.00002890285,0.00002053334,0.0005822486,0.00004568638,0.0002258908,0.9955897,0.0003479638,0.0001439834,0.001598158],"study_design_scores_gemma":[0.0001967161,0.0009063149,0.04125307,0.0000576055,0.0001942256,0.006536426,0.000278547,0.00522685,0.9368845,0.0005616004,0.007860061,0.00004408144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921366,0.0006587347,0.002815198,0.0001392788,0.00004063201,0.00005697675,0.0009384266,0.0004121675,0.002802004],"genre_scores_gemma":[0.9946315,0.0004207718,0.00114935,0.00007564037,0.00001978403,0.00005424514,0.0006065639,0.0001427758,0.002899322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004772563,"threshold_uncertainty_score":0.01596588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01785960437884486,"score_gpt":0.250432343798682,"score_spread":0.2325727394198371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}