{"id":"W2793187279","doi":"10.2147/ott.s148363","title":"Response to crizotinib in a non-small-cell lung cancer patient harboring an &lt;em&gt;EML4-ALK&lt;/em&gt; fusion with an atypical &lt;em&gt;LTBP1&lt;/em&gt; insertion","year":2018,"lang":"en","type":"article","venue":"OncoTargets and Therapy","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"","keywords":"Crizotinib; Anaplastic lymphoma kinase; Lung cancer; Fusion gene; Cancer research; KRAS; Medicine; Cancer; Biology; Oncology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006455649,0.0007453465,0.0008625917,0.0004786852,0.0005596593,0.0002030502,0.0002545258,0.0003258828,0.0004605962],"category_scores_gemma":[0.00004785537,0.0005635588,0.000148818,0.0006950607,0.0001293326,0.0005125715,0.00009450714,0.0003826149,0.0000340101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006755681,"about_ca_system_score_gemma":0.0006227604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004983963,"about_ca_topic_score_gemma":0.007962495,"domain_scores_codex":[0.9958115,0.0003281278,0.0007920145,0.001263941,0.0008126782,0.0009917947],"domain_scores_gemma":[0.9973266,0.0001144003,0.0003029422,0.000887346,0.0005221447,0.0008466295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.07913174,0.007657273,0.06758908,0.0003014144,0.0009500326,0.0006230438,0.08637751,0.0002409333,0.4837424,0.0003441937,0.003137091,0.2699052],"study_design_scores_gemma":[0.03544236,0.03362331,0.6997761,0.002215298,0.0007132752,0.00009122823,0.002848588,0.005376751,0.02171924,0.0001855215,0.1957465,0.002261843],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904993,0.004107514,0.0003024896,0.001087141,0.0007227076,0.002302451,0.00009874561,0.0001630162,0.000716611],"genre_scores_gemma":[0.9900305,0.00198826,0.003277645,0.002117916,0.0007536361,0.0005535731,0.0001635138,0.000173956,0.0009409489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6321871,"threshold_uncertainty_score":0.9996816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01388789291140281,"score_gpt":0.2961615911127861,"score_spread":0.2822736982013833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}