{"id":"W2793187279","doi":"10.2147/ott.s148363","title":"Response to crizotinib in a non-small-cell lung cancer patient harboring an <em>EML4-ALK</em> fusion with an atypical <em>LTBP1</em> insertion","year":2018,"lang":"en","type":"article","venue":"OncoTargets and Therapy","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"","keywords":"Crizotinib; Anaplastic lymphoma kinase; Lung cancer; Fusion gene; Cancer research; KRAS; Medicine; Cancer; Biology; Oncology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001710477,0.0004520085,0.0007048186,0.0003167849,0.0004501993,0.0003043753,0.0003328844,0.0006724611,0.0008097872],"category_scores_gemma":[0.0005178822,0.0001371965,0.0003847853,0.0002357837,0.000189769,0.00017185,0.0001421385,0.00101842,0.0002985724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001042334,"about_ca_system_score_gemma":0.0003148195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002826608,"about_ca_topic_score_gemma":0.006609323,"domain_scores_codex":[0.9998525,0.00002265988,0.00001809711,0.00003519418,0.00002415695,0.00004730879],"domain_scores_gemma":[0.9997824,0.0000527989,0.00002119976,0.000008364593,0.0000209507,0.0001142656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.02302709,0.001574308,0.2683339,0.0005285821,0.0006236145,0.4828599,0.0007519237,0.003969903,0.1145102,0.0002644704,0.004695903,0.0988601],"study_design_scores_gemma":[0.001974165,0.01685745,0.5923695,0.0001018196,0.001058004,0.3367941,0.0005471564,0.01079569,0.02752522,0.0003810264,0.01147084,0.0001250855],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933769,0.002558887,0.0002140553,0.001014886,0.00007109479,0.00006254372,0.0001932249,0.00003636146,0.002472098],"genre_scores_gemma":[0.9986297,0.0003112005,0.0001425276,0.0002369982,0.0000355484,0.000007995732,0.0001919512,0.00000434892,0.0004395894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002826608,"threshold_uncertainty_score":0.007562697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01388789291140281,"score_gpt":0.2961615911127861,"score_spread":0.2822736982013833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}