{"id":"W2793196952","doi":"10.1016/j.pnpbp.2018.03.016","title":"Neurometabolite levels in antipsychotic-naïve/free patients with schizophrenia: A systematic review and meta-analysis of 1H-MRS studies","year":2018,"lang":"en","type":"review","venue":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Schizophrenia (object-oriented programming); Internal medicine; Dorsolateral prefrontal cortex; Choline; Creatine; Thalamus; Glutamine; Medicine; Antipsychotic; Endocrinology; Prefrontal cortex; Neuroscience; Psychology; Psychiatry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001024221,0.001028414,0.01191526,0.001455755,0.00008695351,0.00002393692,0.0005109694,0.0004869488,0.00009853163],"category_scores_gemma":[0.0004189371,0.0005138174,0.001164912,0.002860378,0.001281827,0.00007939391,0.0003016245,0.00114033,0.000005739483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000367847,"about_ca_system_score_gemma":0.0001738583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001885497,"about_ca_topic_score_gemma":0.00003789741,"domain_scores_codex":[0.9933469,0.001830133,0.002078474,0.001598181,0.0004358529,0.0007104556],"domain_scores_gemma":[0.9965315,0.0009737027,0.001036125,0.0008922146,0.0002443081,0.0003221222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.006212504,0.003250496,0.1608688,0.6292025,0.1935529,0.0002333003,0.00002809168,6.599765e-8,3.362292e-8,0.0002321314,0.0002343055,0.006184937],"study_design_scores_gemma":[0.01020778,0.002782333,0.2230575,0.02459886,0.7375859,0.0001064922,0.00001018958,0.000001987332,4.881426e-8,0.0003584831,0.0006549641,0.0006355012],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0230212,0.9682903,3.421952e-7,0.001084695,0.0002675929,0.006937668,0.0003509569,0.00003710813,0.00001013164],"genre_scores_gemma":[0.004760599,0.9911327,0.001031429,0.001114616,0.00005187346,0.001775727,0.00007331668,0.00004628078,0.00001344473],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6046036,"threshold_uncertainty_score":0.9997314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1290191696341299,"score_gpt":0.4270349630534463,"score_spread":0.2980157934193164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}