{"id":"W2793231800","doi":"10.1016/j.autrev.2018.01.006","title":"Bicaudal D2 is a novel autoantibody target in systemic sclerosis that shares a key epitope with CENP-A but has a distinct clinical phenotype","year":2018,"lang":"en","type":"review","venue":"Autoimmunity Reviews","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôpital Maisonneuve-Rosemont; Dalhousie University; Moncton Hospital; Western University; Université de Sherbrooke; McMaster University; University of Manitoba; University of Calgary; McGill University; Jewish General Hospital; University of Alberta; University of Saskatchewan","funders":"Canadian Arthritis Network; Canadian Institutes of Health Research; Norman Cousins Center for Psychoneuroimmunology; Scleroderma Society of Ontario; Jewish General Hospital; Dr. Fooke Laboratorien","keywords":"Autoantibody; Epitope; Epitope mapping; Biology; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.004322442,0.001704362,0.01073615,0.0005618074,0.0004152702,0.0002613989,0.001377723,0.001483246,0.0008740094],"category_scores_gemma":[0.001708728,0.001025458,0.002745048,0.00172129,0.0008365106,0.0002215977,0.0005488344,0.002486051,0.002024077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00052402,"about_ca_system_score_gemma":0.002215313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008861598,"about_ca_topic_score_gemma":0.00004062392,"domain_scores_codex":[0.9888341,0.002460323,0.004990363,0.001674201,0.0009154775,0.001125534],"domain_scores_gemma":[0.9915366,0.0008911635,0.003161906,0.003442702,0.0003292936,0.0006383779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002985678,0.002967702,0.00636173,0.1378813,0.002408835,0.0001168977,0.0007080971,2.740077e-7,0.00003540368,0.0000287081,0.02177687,0.8274156],"study_design_scores_gemma":[0.00150335,0.0003779088,0.003830667,0.3838761,0.003596682,0.0003404778,0.00005667526,0.00002672671,7.776201e-7,0.000001725206,0.6056371,0.0007517128],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001534655,0.9886916,0.00005049328,0.000137967,0.00092749,0.00723295,0.0006559762,0.0002515676,0.0005173232],"genre_scores_gemma":[0.001860374,0.9933072,0.0006979962,0.0004435093,0.0006768053,0.0008339404,0.001134807,0.0002841695,0.0007612508],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8266639,"threshold_uncertainty_score":0.9998152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.303625450192674,"score_gpt":0.3883283391195522,"score_spread":0.08470288892687827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}