{"id":"W2793235655","doi":"10.1093/jcag/gwy009.028","title":"A28 SHP-1 REGULATES INTESTINAL EPITHELIUM HOMEOSTASIS BY CONTROLLING ACTIVATION OF BOTH PI3K/AKT AND WNT/β-CATENIN PATHWAYS","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; Wnt signaling pathway; Intestinal epithelium; Cell biology; Protein tyrosine phosphatase; Biology; Catenin; LGR5; PTEN; Stem cell; Beta-catenin; Epithelium; Signal transduction; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009418172,0.0003838412,0.0001890626,0.0003420702,0.0001986956,0.0002997029,0.00024999,0.0002585938,0.002798733],"category_scores_gemma":[0.00008623306,0.0001540299,0.0002783859,0.0001398106,0.0002532013,0.0002422015,0.0003728852,0.0008138357,0.0007306844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002506889,"about_ca_system_score_gemma":0.0002159257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004668071,"about_ca_topic_score_gemma":0.0007253948,"domain_scores_codex":[0.9998851,0.00001016382,0.000006550039,0.0000273789,0.00003990911,0.00003090969],"domain_scores_gemma":[0.9999068,0.000003546373,0.00003157148,0.000005553534,0.00000880029,0.0000436911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002293163,0.00003772735,0.0007879225,0.00007207767,0.0000105783,0.0001186264,0.00001596571,0.0001503542,0.9946426,0.000206227,0.0001974202,0.003531124],"study_design_scores_gemma":[0.0001411717,0.0007775234,0.06522685,0.00004239548,0.00009427142,0.0009649614,0.0002077973,0.004806144,0.9105464,0.0006866975,0.01648582,0.00002005505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900318,0.003419571,0.002270788,0.000226585,0.00004673983,0.00002782114,0.0008437919,0.0001718227,0.002960998],"genre_scores_gemma":[0.9935975,0.001430625,0.0007426443,0.00005105575,0.00001111757,0.00003143984,0.0005773742,0.0000212422,0.003537077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002798733,"threshold_uncertainty_score":0.009362698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009445007918572225,"score_gpt":0.2166410681314845,"score_spread":0.2071960602129122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}