{"id":"W2793247508","doi":"10.1093/cercor/bhx294","title":"Amyloid Network Topology Characterizes the Progression of Alzheimer’s Disease During the Predementia Stages","year":2017,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Northern California Institute for Research and Education; European Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; Marcus och Amalia Wallenbergs minnesfond; Servier; Karolinska Institutet; Vetenskapsrådet; DoD Alzheimer's Disease Neuroimaging Initiative; BioClinica; Pfizer; Novartis Pharmaceuticals Corporation; Alzheimer's Association; Åke Wiberg Stiftelse; Hjärnfonden; F. Hoffmann-La Roche; Roche; National Institute on Aging; Merck; Takeda Pharmaceutical Company; Eli Lilly and Company; Bristol-Myers Squibb; GE Healthcare","keywords":"Cerebrospinal fluid; Dementia; Amyloid (mycology); Positron emission tomography; Alzheimer's disease; Neuroscience; β amyloid; Pathology; Medicine; Disease; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0002150509,0.0001491766,0.0001696144,0.00001738353,0.002052001,0.0001073437,0.0006490665,0.0000316689,0.0001346317],"category_scores_gemma":[0.001685633,0.00008081272,0.00009633813,0.00005875592,0.0008536762,0.0002296785,0.0006327996,0.0001635323,0.00001942067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009727405,"about_ca_system_score_gemma":0.00003545802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001965168,"about_ca_topic_score_gemma":0.00002686057,"domain_scores_codex":[0.9986793,0.000179347,0.000193082,0.0003662399,0.0002711724,0.0003108293],"domain_scores_gemma":[0.9980721,0.0006712467,0.0003465905,0.0008156594,0.00003994698,0.00005445799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008099104,0.0002258952,0.770758,0.00009614554,0.0002135786,0.00004349263,0.0005578048,0.00006548878,0.1962123,0.01449264,0.007707365,0.008817316],"study_design_scores_gemma":[0.0002273698,0.00006596259,0.9759896,0.00003018399,0.00005430511,0.00000455909,0.00003135802,0.00008929452,0.01971286,0.0006656198,0.003029306,0.00009956777],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837543,0.0003993717,0.000005942592,0.01325698,0.001025385,0.0005002709,0.00003102684,0.00004781186,0.0009788462],"genre_scores_gemma":[0.9980343,0.00005734478,0.00001052628,0.000785203,0.0003891425,0.00007571097,0.000001616664,0.00001450204,0.0006316467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2052315,"threshold_uncertainty_score":0.9992472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03969197582703132,"score_gpt":0.3005855733187123,"score_spread":0.260893597491681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}