{"id":"W2793247508","doi":"10.1093/cercor/bhx294","title":"Amyloid Network Topology Characterizes the Progression of Alzheimer’s Disease During the Predementia Stages","year":2017,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Northern California Institute for Research and Education; European Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; Marcus och Amalia Wallenbergs minnesfond; Servier; Karolinska Institutet; Vetenskapsrådet; DoD Alzheimer's Disease Neuroimaging Initiative; BioClinica; Pfizer; Novartis Pharmaceuticals Corporation; Alzheimer's Association; Åke Wiberg Stiftelse; Hjärnfonden; F. Hoffmann-La Roche; Roche; National Institute on Aging; Merck; Takeda Pharmaceutical Company; Eli Lilly and Company; Bristol-Myers Squibb; GE Healthcare","keywords":"Cerebrospinal fluid; Dementia; Amyloid (mycology); Positron emission tomography; Alzheimer's disease; Neuroscience; β amyloid; Pathology; Medicine; Disease; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003919997,0.0002738313,0.00021719,0.001494708,0.0001564395,0.0004259201,0.0001812378,0.0002254441,0.0006715175],"category_scores_gemma":[0.002544606,0.0001631296,0.000205053,0.0005750505,0.0002526105,0.0006686141,0.0003199101,0.0002050401,0.00008735277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002573573,"about_ca_system_score_gemma":0.0001111453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001761593,"about_ca_topic_score_gemma":0.003027206,"domain_scores_codex":[0.9998473,0.00005288174,0.0000138206,0.00003680067,0.00002579803,0.00002346627],"domain_scores_gemma":[0.9987867,0.0003827543,0.0005177598,0.00007034858,0.0001185326,0.0001237367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008933728,0.00008309011,0.947091,0.00008607101,0.0003828168,0.0006185221,0.001078529,0.006430226,0.01705957,0.001041175,0.0002975052,0.02493811],"study_design_scores_gemma":[0.0000054727,0.0000898487,0.9896422,0.000009366931,0.00004687224,0.0006120442,0.0001785366,0.00680123,0.0006805976,0.00170891,0.0002155755,0.000009425537],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982778,0.0001511958,0.00108534,0.00002052031,0.000001248247,0.000006226989,0.00012602,0.000009881496,0.0003218935],"genre_scores_gemma":[0.9990458,0.0001138967,0.0006022617,0.00000302509,0.000002696458,0.000007327777,0.0001591068,0.000002106884,0.00006377194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001761593,"threshold_uncertainty_score":0.003502727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03969197582703132,"score_gpt":0.3005855733187123,"score_spread":0.260893597491681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}