{"id":"W2793257861","doi":"10.1002/cpdd.439","title":"Systemic Pharmacokinetics, Safety, and Preliminary Efficacy of Topical AhR Agonist Tapinarof: Results of a Phase 1 Study","year":2018,"lang":"en","type":"article","venue":"Clinical Pharmacology in Drug Development","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"GlaxoSmithKline","keywords":"Medicine; Tolerability; Pharmacokinetics; Nonsteroidal; Atopic dermatitis; Incidence (geometry); Cohort; Adverse effect; Safety profile; Open label; Pharmacology; Dermatology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001260473,0.0002208208,0.0009720639,0.0001742922,0.00007191567,0.000002636174,0.0002242743,0.000165959,0.00012385],"category_scores_gemma":[0.0005793644,0.0001931716,0.00009390002,0.000204833,0.001192688,0.00003424748,0.0002821543,0.0003773131,0.00002111796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005408663,"about_ca_system_score_gemma":0.0004234234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001003489,"about_ca_topic_score_gemma":0.000006087994,"domain_scores_codex":[0.9961643,0.0005861406,0.00220761,0.000514509,0.0002207701,0.0003066305],"domain_scores_gemma":[0.9976533,0.001247708,0.0003983435,0.0002542932,0.0001979816,0.0002483693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1312719,0.04707219,0.6948502,0.001059692,0.001746206,0.001994508,0.01237836,0.000008557161,0.005722956,0.00001903136,0.06714465,0.03673174],"study_design_scores_gemma":[0.07894621,0.003382866,0.8885295,0.0003671765,0.000709124,0.0002070693,0.0008421693,0.0002219957,0.0201107,0.00001753016,0.006393707,0.0002719747],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949939,0.0006590399,0.00001818943,0.0009004054,0.00113665,0.001355902,0.0000166926,0.00003069731,0.0008885194],"genre_scores_gemma":[0.998165,0.0002672395,0.000436157,0.0004989507,0.0002321783,0.00004125258,0.00002511665,0.00001522478,0.0003189427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1936793,"threshold_uncertainty_score":0.7877309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0443249687538772,"score_gpt":0.4239657936168991,"score_spread":0.3796408248630219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}