{"id":"W2793269909","doi":"10.1016/j.brainres.2018.03.013","title":"bHLH transcription factors in neural development, disease, and reprogramming","year":2018,"lang":"en","type":"review","venue":"Brain Research","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":262,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Reprogramming; Biology; Transcription factor; Embryonic stem cell; Induced pluripotent stem cell; Neuroscience; Progenitor cell; Neural development; Cell type; Cellular differentiation; Neurogenesis; Neural stem cell; Cell fate determination; Somatic cell; Neuroepithelial cell; Neural cell; Stem cell; Cell biology; Genetics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002415704,0.000341231,0.000550577,0.0005574021,0.0002040872,0.0001399959,0.0005620336,0.0004004873,0.00002541059],"category_scores_gemma":[0.000796441,0.0002912428,0.0001740796,0.0005682512,0.0003628648,0.000007439472,0.0004937963,0.0006882885,0.00003884862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000102678,"about_ca_system_score_gemma":0.0007118279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003497909,"about_ca_topic_score_gemma":0.0001290508,"domain_scores_codex":[0.9957097,0.001064896,0.0004892775,0.001116334,0.0006900225,0.0009297353],"domain_scores_gemma":[0.9986371,0.0001649879,0.00007049228,0.0006194546,0.0001467988,0.0003612105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000722039,0.0001187568,0.0006503675,0.01088309,0.0001124875,0.00006657242,0.000103519,2.273685e-7,0.001035429,0.00001049602,0.003595117,0.9833517],"study_design_scores_gemma":[0.0001931521,0.0001108311,0.0005484436,0.001556668,0.00001402851,0.000008770095,0.00003462276,0.00001099439,0.0001219669,0.00000732041,0.9971033,0.000289845],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01272471,0.9854829,0.00001452951,0.00007043534,0.00006926904,0.001358162,0.00002527803,0.00001370229,0.0002410201],"genre_scores_gemma":[0.001559128,0.9923898,0.0001201558,0.0000118673,0.000221518,0.000290618,0.0008471002,0.00008011935,0.004479714],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9935082,"threshold_uncertainty_score":0.999954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1556396880655553,"score_gpt":0.4243032923590006,"score_spread":0.2686636042934452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}