{"id":"W2793280128","doi":"10.1016/j.expneurol.2018.01.013","title":"Secreted amyloid precursor protein alpha activates neuronal insulin receptors and prevents diabetes-induced encephalopathy","year":2018,"lang":"en","type":"article","venue":"Experimental Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Alzheimer Society of Manitoba; Canadian Institutes of Health Research; Canadian Diabetes Association","keywords":"Hyperphosphorylation; Amyloid precursor protein; Internal medicine; Endocrinology; Phosphorylation; Insulin; Amyloid (mycology); Receptor; Insulin receptor; Amyloid beta; Chemistry; Biology; Cell biology; Alzheimer's disease; Peptide; Biochemistry; Medicine; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002933527,0.0005341527,0.0006630092,0.0005396131,0.0002462521,0.0005580899,0.0004546835,0.0004615174,0.001444735],"category_scores_gemma":[0.0004839401,0.0002487501,0.0003666259,0.0002781094,0.0006261136,0.000470874,0.000260873,0.001152194,0.000422488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002020435,"about_ca_system_score_gemma":0.0003820627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003719736,"about_ca_topic_score_gemma":0.0004615566,"domain_scores_codex":[0.9998106,0.00004175074,0.00002215784,0.00002048021,0.00003361245,0.00007140214],"domain_scores_gemma":[0.9996949,0.00005109151,0.00006171317,0.00005853873,0.00002334513,0.0001103486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02531978,0.003632187,0.001329497,0.0001867745,0.000152661,0.000767766,0.0001319894,0.0003626616,0.9454331,0.0008040469,0.0005348321,0.0213447],"study_design_scores_gemma":[0.00398829,0.01418109,0.01373155,0.00005454737,0.0002590152,0.001416969,0.0003245992,0.001488021,0.9593945,0.001051886,0.004076438,0.00003301393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966202,0.001112465,0.0006358319,0.0001162275,0.0000992019,0.00002297305,0.00006108663,0.00007681074,0.001255161],"genre_scores_gemma":[0.9959083,0.001186336,0.0005334773,0.00006852516,0.00004105328,0.00002471078,0.0002220562,0.00002540909,0.001990076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001444735,"threshold_uncertainty_score":0.004833102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02026867608870598,"score_gpt":0.2993938910434032,"score_spread":0.2791252149546972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}