{"id":"W2793319096","doi":"10.1016/j.actbio.2018.02.020","title":"Esterase from a cariogenic bacterium hydrolyzes dental resins","year":2018,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; University of Toronto","funders":"National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research","keywords":"Methacrylate; Hydrolysis; Esterase; Monomer; Materials science; Streptococcus mutans; Bacteria; Dental plaque; Polymer chemistry; Enzyme; Microbiology; Biochemistry; Composite material; Chemistry; Polymer; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005688052,0.000152741,0.0001284779,0.00003517622,0.00007434513,0.00009732778,0.0001886264,0.0001458278,0.0003233007],"category_scores_gemma":[0.00002598354,0.000140402,0.00007189067,0.00007492115,0.000103713,0.00001020883,0.0001330975,0.00001395298,0.0001086607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001510436,"about_ca_system_score_gemma":0.00002344428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000215527,"about_ca_topic_score_gemma":0.0002994938,"domain_scores_codex":[0.9991058,0.00004982899,0.0002048743,0.0003599318,0.00008534961,0.0001942431],"domain_scores_gemma":[0.9993495,0.000002535623,0.00008150762,0.000440338,0.00005687748,0.00006918853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001089187,0.00004948546,0.001388538,0.000003536829,0.00005592045,0.000001779518,0.00005767072,3.159671e-8,0.9933831,0.000002492631,0.004863517,0.00008501986],"study_design_scores_gemma":[0.0003491296,0.0002375745,0.007103612,0.000008182898,0.00003353049,0.000007262268,0.00002171012,0.000006628336,0.9472896,0.000008016339,0.04476107,0.000173652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980611,0.00008670703,0.00007402781,0.00004877345,0.001236937,0.00009364392,0.0001994754,0.0000237827,0.0001755282],"genre_scores_gemma":[0.9953309,0.000020586,0.0001681967,0.0001872894,0.001135715,0.00001210558,0.00268432,0.00002702006,0.0004338914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04609346,"threshold_uncertainty_score":0.5725426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007504135205254996,"score_gpt":0.2363226057515143,"score_spread":0.2288184705462593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}