{"id":"W2793343392","doi":"10.1016/j.bmcl.2018.03.016","title":"Design, synthesis, nuclear localization, and biological activity of a fluorescent duocarmycin analog, HxTfA","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Cancer Research UK; National Science Foundation","keywords":"Chemistry; Confocal microscopy; Confocal; Cytotoxicity; Fluorescence; A549 cell; Fluorescence microscope; In vitro; Biological activity; Biochemistry; Biophysics; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002342647,0.0001963968,0.0001789409,0.0001201369,0.000231922,0.0003580867,0.0003552003,0.000223651,0.001096049],"category_scores_gemma":[0.0002156714,0.0001373049,0.0001610423,0.0001487749,0.0002382337,0.0002347931,0.0001396362,0.0003386422,0.0002797977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006822931,"about_ca_system_score_gemma":0.0004142202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001328499,"about_ca_topic_score_gemma":0.001381709,"domain_scores_codex":[0.9998922,0.00001672264,0.00001257973,0.00003229675,0.00002113037,0.00002499094],"domain_scores_gemma":[0.9998677,0.00002403108,0.00003716686,0.00002282119,0.00001831361,0.00002987124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001648122,0.00004168385,0.0001485002,0.00005632703,0.000003823719,0.00006289309,0.00004463099,0.0005579563,0.9927917,0.001018694,0.00007947916,0.005029562],"study_design_scores_gemma":[0.00001116316,0.00008104224,0.0001740247,0.00000181822,0.000003506891,0.00004494903,0.000006690955,0.0004887935,0.9970175,0.00002814615,0.002139479,0.0000028638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708839,0.0009762666,0.02231299,0.0002747823,0.00003895978,0.0001734975,0.0005747903,0.000208284,0.004556466],"genre_scores_gemma":[0.9839652,0.0005257396,0.01162847,0.00005478977,0.00000851331,0.00005656258,0.0005143002,0.0000409494,0.003205355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001328499,"threshold_uncertainty_score":0.004950404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01658258302948175,"score_gpt":0.2284189093719077,"score_spread":0.211836326342426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}