{"id":"W2793350940","doi":"10.1038/s41388-017-0103-1","title":"Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore","year":2018,"lang":"en","type":"article","venue":"Oncogene","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Novartis Pharma; Alberta Cancer Foundation","keywords":"Apoptosis; Mitochondrial permeability transition pore; Biology; Cell biology; Mitochondrion; Programmed cell death; Autophagy; Mitochondrial apoptosis-induced channel; Cyclin-dependent kinase 5; Cancer cell; Intrinsic apoptosis; Intracellular; Mitochondrial fission; Cancer research; Cancer; Cell cycle; Cytochrome c; Caspase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009618868,0.0002788715,0.0002212735,0.0001969657,0.0002009768,0.000255265,0.0001587606,0.0001667629,0.00121293],"category_scores_gemma":[0.0001034461,0.0001009415,0.000216484,0.000182095,0.000193565,0.0001973793,0.0001369924,0.0003805241,0.0002349023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005194133,"about_ca_system_score_gemma":0.0002668926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001281267,"about_ca_topic_score_gemma":0.001902726,"domain_scores_codex":[0.9998938,0.00001463047,0.00001233932,0.00001797723,0.00003035726,0.00003083879],"domain_scores_gemma":[0.9999572,0.000008202215,0.00001186781,0.000006027413,0.000004006371,0.00001256964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001845041,0.00003574098,0.0008325686,0.00005907765,0.00001100704,0.000146572,0.00001598632,0.000138164,0.9965028,0.0001890557,0.00004842169,0.001836147],"study_design_scores_gemma":[0.00001101042,0.0001540164,0.004430343,0.000004517253,0.00001448861,0.0003966288,0.00002749689,0.0007206899,0.9921588,0.00004339002,0.002036423,0.00000233521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929578,0.003025186,0.002137275,0.000119217,0.00002203858,0.00001767344,0.0003544876,0.00004128524,0.001324991],"genre_scores_gemma":[0.9967416,0.0009213851,0.001142852,0.00002264019,0.00000274642,0.00001523078,0.0002572335,0.000004678247,0.00089163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001281267,"threshold_uncertainty_score":0.004057646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068802804663975,"score_gpt":0.2476276986216342,"score_spread":0.2369396705749945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}