{"id":"W2793350940","doi":"10.1038/s41388-017-0103-1","title":"Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore","year":2018,"lang":"en","type":"article","venue":"Oncogene","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Novartis Pharma; Alberta Cancer Foundation","keywords":"Apoptosis; Mitochondrial permeability transition pore; Biology; Cell biology; Mitochondrion; Programmed cell death; Autophagy; Mitochondrial apoptosis-induced channel; Cyclin-dependent kinase 5; Cancer cell; Intrinsic apoptosis; Intracellular; Mitochondrial fission; Cancer research; Cancer; Cell cycle; Cytochrome c; Caspase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009900178,0.0001166905,0.000172503,0.00002308159,0.00003774947,0.000003106641,0.0001232581,0.0002108353,0.0001579444],"category_scores_gemma":[0.00002012523,0.00009041918,0.00009933593,0.0001463223,0.0001934598,0.000005549311,0.00003274039,0.0000628031,0.000002646455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002129437,"about_ca_system_score_gemma":0.0001277833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002178051,"about_ca_topic_score_gemma":0.0003793499,"domain_scores_codex":[0.9990215,0.0001458292,0.000294751,0.000269652,0.0001227459,0.0001454892],"domain_scores_gemma":[0.9993169,0.00001143391,0.000155706,0.0003057563,0.0001822257,0.00002792541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004035847,0.0001492074,0.005233003,0.0000343477,0.00001075857,5.842458e-7,0.0003676994,0.00008751982,0.9932906,0.000009433036,0.0001887545,0.0002245071],"study_design_scores_gemma":[0.0009593025,0.0002110023,0.0101577,0.00002101014,0.00002272366,0.000009419817,0.0000374172,0.00008832954,0.9873738,0.00009808296,0.0009269537,0.00009429846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996941,0.0000852607,0.000985464,0.000251358,0.0007686362,0.0003221771,0.0002857403,0.000004582542,0.0003558153],"genre_scores_gemma":[0.9982994,0.0000518954,0.0007514536,0.0001034435,0.0005055866,0.00001716704,0.0001385434,0.00001263986,0.0001198797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005916842,"threshold_uncertainty_score":0.3687187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068802804663975,"score_gpt":0.2476276986216342,"score_spread":0.2369396705749945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}