{"id":"W2793432303","doi":"10.1111/acel.12723","title":"Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults","year":2018,"lang":"en","type":"article","venue":"Aging Cell","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":180,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; Fondation pour la Recherche Médicale; National Institutes of Health; New York State Department of Health; National Center for Advancing Translational Sciences; Glenn Foundation for Medical Research; Burroughs Wellcome Fund","keywords":"Metformin; Adipose tissue; Endocrinology; Biology; Internal medicine; Insulin resistance; Glucose uptake; Skeletal muscle; Insulin; Pharmacology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001807461,0.0001746828,0.0002794928,0.00007610474,0.00004285758,0.00001727175,0.0001078747,0.0001063576,0.00002912664],"category_scores_gemma":[0.00002115741,0.000162173,0.00004426202,0.0001015566,0.0001853348,0.000009671623,0.0001031367,0.00006416116,0.000003659814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002721231,"about_ca_system_score_gemma":0.00002513076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001489678,"about_ca_topic_score_gemma":0.0001184424,"domain_scores_codex":[0.9989755,0.00004758977,0.000228296,0.000368174,0.00009928182,0.0002811669],"domain_scores_gemma":[0.9994871,0.00001386934,0.00009160468,0.0002658595,0.00005760177,0.00008393733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004688543,0.0001120922,0.003135869,0.0001602785,0.00005471351,0.0000120091,0.002358406,0.000001856538,0.3612715,0.0001155147,0.000151289,0.6325796],"study_design_scores_gemma":[0.001106611,0.0001804563,0.01938888,0.00005180973,0.0000692755,0.00002154884,0.000238124,0.00008013238,0.8689453,0.0001247912,0.1095059,0.0002871889],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6823939,0.3171439,0.000008546918,0.000003903606,0.00007817853,0.000103757,0.00001221877,0.000006140594,0.0002494458],"genre_scores_gemma":[0.9594557,0.03954667,0.0005090418,0.00009256772,0.0002159085,0.000009897512,0.00001979707,0.00002455968,0.0001258825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6322924,"threshold_uncertainty_score":0.6613224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00428428113193048,"score_gpt":0.2094057918159795,"score_spread":0.205121510684049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}