{"id":"W2793444178","doi":"10.1016/j.ccell.2018.01.018","title":"The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma","year":2018,"lang":"es","type":"article","venue":"Cancer Cell","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":161,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver Coastal Health Research Institute; University of British Columbia; Vancouver Coastal Health","funders":"National Cancer Institute; Canadian Cancer Society Research Institute; National Institutes of Health; Terry Fox Research Institute; Howard Hughes Medical Institute","keywords":"Synovial sarcoma; Demethylase; Biology; Cell biology; Histone; Repressor; Epigenetics; Psychological repression; DNA methylation; Genetics; Gene; Cancer research; Gene expression; Sarcoma; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002449292,0.0004722625,0.0005430861,0.00006495038,0.0005576045,0.0001742642,0.0004283425,0.0002079094,0.002462198],"category_scores_gemma":[0.0000695944,0.0003176839,0.0002504665,0.0002992919,0.0003756071,0.00007846027,0.0002257183,0.0002841837,0.0038149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001036366,"about_ca_system_score_gemma":0.0005049274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004037435,"about_ca_topic_score_gemma":0.001730073,"domain_scores_codex":[0.9971949,0.0001227787,0.0004725961,0.0007215804,0.0005651169,0.0009230587],"domain_scores_gemma":[0.9976395,0.000300962,0.0001863548,0.001050789,0.0002912957,0.0005311063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001715798,0.002271492,0.1180565,0.0003499592,0.001123897,0.000622452,0.005009382,0.000006682761,0.01488889,0.00224559,0.2926978,0.5610116],"study_design_scores_gemma":[0.003111674,0.002265749,0.02965122,0.0007156927,0.0005109364,0.00001083941,0.000694737,0.00005709039,0.1509997,0.0001138755,0.811423,0.0004454636],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8876113,0.05377755,0.00003648197,0.01288102,0.003986894,0.002467453,0.0001632249,0.0001043292,0.0389717],"genre_scores_gemma":[0.9794356,0.00493065,0.0002091838,0.002655924,0.005476505,0.0006744453,0.00001107516,0.00009411934,0.006512503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5605661,"threshold_uncertainty_score":0.9999275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01627371450816894,"score_gpt":0.3038737612487357,"score_spread":0.2876000467405668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}