{"id":"W2793449736","doi":"10.1016/j.antiviral.2018.02.017","title":"Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A","year":2018,"lang":"en","type":"article","venue":"Antiviral Research","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"AIDS Vancouver; Jewish General Hospital; McGill University; University of British Columbia; Université de Sherbrooke; Simon Fraser University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Viral replication; Long terminal repeat; Peripheral blood mononuclear cell; NF-κB; Reporter gene; HIV Long Terminal Repeat; Gene; Virology; Cell culture; Gene expression; Molecular biology; Cell biology; Signal transduction; In vitro; Genetics; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001785305,0.0001081666,0.000148984,0.0001381638,0.0004153045,0.00002486443,0.0002786102,0.00008007139,0.0002371135],"category_scores_gemma":[0.0006746852,0.00006819674,0.00005506474,0.000360457,0.001038238,0.0001143221,0.0003392983,0.0005958682,0.003227861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007239285,"about_ca_system_score_gemma":0.0001051495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008001299,"about_ca_topic_score_gemma":0.0002011113,"domain_scores_codex":[0.9978896,0.0007054669,0.0002178635,0.0004297586,0.0002176459,0.0005396768],"domain_scores_gemma":[0.9984648,0.0002582943,0.00005737818,0.0007366809,0.000466163,0.00001671137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003046502,0.000224067,0.005849442,0.00001431352,0.00008271253,0.000004322534,0.0002326573,1.3385e-8,0.8921531,0.0004536086,0.05345347,0.04722767],"study_design_scores_gemma":[0.0007247913,0.0005480095,0.01333544,0.00001914684,0.000007093993,0.0000159108,0.000160219,0.000003305175,0.9725265,0.0003053114,0.01228574,0.00006854496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847772,0.001234385,0.00001333581,0.00275503,0.000100065,0.0006716173,0.0001048682,0.00002800768,0.01031551],"genre_scores_gemma":[0.9753771,0.0001523876,0.00001826023,0.00002449271,0.00007584292,0.00008031694,0.0006103326,0.00001199291,0.02364927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08037341,"threshold_uncertainty_score":0.9975482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03573369459454651,"score_gpt":0.3503164268284042,"score_spread":0.3145827322338577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}