{"id":"W2793475974","doi":"10.1080/14756366.2018.1437155","title":"Synthesis and biological evaluation of<i>N</i>-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2<i>H</i>,4<i>H</i>)-dione as potential antiplatelet agents","year":2018,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculté de pharmacie, Université de Montréal; Narodowym Centrum Nauki; Uniwersytet Jagielloński Collegium Medicum","keywords":"Clopidogrel; Chemistry; Pharmacology; Aspirin; Mechanism of action; Receptor; Platelet; Alpha (finance); Platelet aggregation; Stereochemistry; In vitro; Medicine; Biochemistry; Internal medicine; Surgery","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00102988,0.0001367501,0.0003071806,0.00005206218,0.00005131214,0.000007561462,0.00006548549,0.0001741475,0.0002759682],"category_scores_gemma":[0.0005301739,0.0001071806,0.00008476833,0.00007503152,0.0003180196,0.00001301216,0.00005074674,0.0001126479,2.979463e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008905078,"about_ca_system_score_gemma":0.00009668166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004314294,"about_ca_topic_score_gemma":3.417213e-7,"domain_scores_codex":[0.9987024,0.00008855724,0.0005217328,0.0001739222,0.0003888768,0.0001244863],"domain_scores_gemma":[0.9985945,0.00003124468,0.0004936323,0.00009459484,0.0006705978,0.0001154613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003476134,0.00006987183,0.0001981857,0.00005907051,0.00007527329,0.000006446326,0.000076685,0.000007375711,0.995719,0.000008365421,0.0002741038,0.00315806],"study_design_scores_gemma":[0.001287216,0.0007143422,0.0005129697,0.0002522789,0.0001175084,0.0004620606,0.000381244,0.00009344084,0.9955183,0.0002142006,0.0003439618,0.0001024235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956928,0.00254441,0.001161942,0.0001187717,0.00009763263,0.00007083164,0.00001135333,0.000002125334,0.0003000767],"genre_scores_gemma":[0.9974028,0.001202892,0.000731276,0.00009236552,0.0005232736,0.000002195401,0.00001863034,0.000008860551,0.00001765903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003055636,"threshold_uncertainty_score":0.4370698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02315334790137174,"score_gpt":0.2898049013742993,"score_spread":0.2666515534729276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}