{"id":"W2793475974","doi":"10.1080/14756366.2018.1437155","title":"Synthesis and biological evaluation of<i>N</i>-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2<i>H</i>,4<i>H</i>)-dione as potential antiplatelet agents","year":2018,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculté de pharmacie, Université de Montréal; Narodowym Centrum Nauki; Uniwersytet Jagielloński Collegium Medicum","keywords":"Clopidogrel; Chemistry; Pharmacology; Aspirin; Mechanism of action; Receptor; Platelet; Alpha (finance); Platelet aggregation; Stereochemistry; In vitro; Medicine; Biochemistry; Internal medicine; Surgery","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001211549,0.0002854621,0.0001988416,0.000195046,0.0001282983,0.000104255,0.0002890189,0.0002100062,0.001172208],"category_scores_gemma":[0.0001143659,0.00009142144,0.0001976554,0.0001787303,0.000120556,0.0001950204,0.0001392389,0.0002924058,0.0002971021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001397794,"about_ca_system_score_gemma":0.0001662704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003830045,"about_ca_topic_score_gemma":0.0006525646,"domain_scores_codex":[0.9999462,0.00001283715,0.000006423719,0.000009035469,0.00001082827,0.00001456584],"domain_scores_gemma":[0.9999487,0.000007702176,0.00001528308,0.000004600442,0.000008617797,0.00001513541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002209774,0.0002148013,0.0001283829,0.0003924392,0.00001817328,0.0003328963,0.00004892711,0.001339713,0.9844868,0.0007409247,0.0002958132,0.01178023],"study_design_scores_gemma":[0.0002406707,0.006329265,0.003295095,0.00004944267,0.00008133873,0.0006656357,0.00004078501,0.002511543,0.9704495,0.0003431053,0.0159572,0.00003655899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.957046,0.01453878,0.01435222,0.0003504615,0.000144998,0.000327724,0.0009393462,0.0001696916,0.01213069],"genre_scores_gemma":[0.9814446,0.007883228,0.007218042,0.0001626536,0.00004841915,0.00009824032,0.0005497558,0.00001547805,0.002579615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001172208,"threshold_uncertainty_score":0.003921449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02315334790137174,"score_gpt":0.2898049013742993,"score_spread":0.2666515534729276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}