{"id":"W2793493399","doi":"10.1073/pnas.1715713115","title":"The secreted metabolome of <i>Streptomyces chartreusis</i> and implications for bacterial chemistry","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island","funders":"German Network for Bioinformatics Infrastructure; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft","keywords":"Metabolome; Chemistry; Streptomyces; Computational biology; Biochemistry; Bacteria; Tandem mass spectrometry; Biology; Mass spectrometry; Chromatography; Genetics; Metabolite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006973174,0.00005728142,0.0001330728,0.0000290573,0.000218983,0.00001246562,0.0002762439,0.00005348059,0.00001329347],"category_scores_gemma":[0.0007383205,0.00002760734,0.00005281857,0.0002699675,0.001373339,0.0001013648,0.00007055839,0.00005408697,1.166265e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006657799,"about_ca_system_score_gemma":0.00003118452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000176645,"about_ca_topic_score_gemma":3.525316e-8,"domain_scores_codex":[0.9992835,0.000001894024,0.0002288462,0.0001539003,0.0002410244,0.0000908328],"domain_scores_gemma":[0.9989943,0.0001238079,0.0003237222,0.00001034488,0.0005284921,0.0000193705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005021553,0.00001277175,0.0007322794,0.00008030447,0.0000194428,1.084544e-10,0.00003970694,1.971482e-8,0.9939829,0.003487741,0.0009145926,0.0006800717],"study_design_scores_gemma":[0.000146806,0.00004196975,0.02570857,0.00004184521,0.00003686624,0.000005839971,0.00005221545,0.00001506448,0.9652776,0.003541716,0.005100325,0.00003122512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746873,0.0002137407,1.098792e-7,0.02402105,0.00001584931,0.0002162981,0.00005989243,0.000004363072,0.000781403],"genre_scores_gemma":[0.9987202,0.00007066402,0.0006504236,0.0001368777,0.0002233244,0.000002733203,3.841149e-7,0.000002155307,0.0001932603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0287053,"threshold_uncertainty_score":0.5060125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0309108254809607,"score_gpt":0.3028680405741916,"score_spread":0.271957215093231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}