{"id":"W2793503352","doi":"10.1371/journal.pone.0191345","title":"Impaired memory is more closely associated with brain beta-amyloid than leukoaraiosis in hypertensive patients with cognitive symptoms","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; H. Lundbeck A/S; Biogen; Fidelity Biosciences; Eli Lilly and Company; Bristol-Myers Squibb; National Institute of Mental Health; Pfizer; F. Hoffmann-La Roche; Alzheimer's Drug Discovery Foundation; Eisai; National Institute on Aging; Alzheimer's Association","keywords":"Leukoaraiosis; Dementia; Pittsburgh compound B; Episodic memory; Medicine; Hyperintensity; Internal medicine; Cardiology; Clinical Dementia Rating; Stroke (engine); Cognitive decline; Neuropsychology; Neuroimaging; Magnetic resonance imaging; Memory clinic; Psychology; Cognition; Psychiatry; Disease; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005809357,0.0004086478,0.0005483297,0.0008335774,0.0005687719,0.000771234,0.0002788893,0.0006688875,0.002332134],"category_scores_gemma":[0.002614642,0.0004740685,0.0004824405,0.0009274309,0.0003923108,0.0004929122,0.000353572,0.0009076279,0.0003395939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001841442,"about_ca_system_score_gemma":0.0002829875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002489486,"about_ca_topic_score_gemma":0.003023677,"domain_scores_codex":[0.9996176,0.00009313585,0.00004819233,0.00009302879,0.00008496581,0.00006315689],"domain_scores_gemma":[0.9979539,0.0003812652,0.0009994643,0.0001262174,0.0001585504,0.0003805447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001203938,0.00003391171,0.9989105,0.000004702075,0.00005507833,0.0001366574,0.00003613768,0.00001363118,0.0001861675,0.000005890045,0.00003106994,0.0004658876],"study_design_scores_gemma":[0.000008453638,0.0000821672,0.9992481,0.000002928727,0.00003395052,0.0004364236,0.00004191354,0.0000676952,0.00003033919,0.00001580521,0.00002971449,0.000002456084],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993134,0.0002092808,0.00006069482,0.00004006394,0.00001061587,0.000004264913,0.00006137186,0.000003894143,0.0002964464],"genre_scores_gemma":[0.9997239,0.0000553253,0.00003376554,0.00002261534,0.00002458396,0.000002941595,0.00007068175,0.000001170965,0.00006510036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002489486,"threshold_uncertainty_score":0.007801712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02980882697856212,"score_gpt":0.2590150818671865,"score_spread":0.2292062548886244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}