{"id":"W2793511964","doi":"10.1093/ecco-jcc/jjx180.978","title":"P851 Oral delivery of Human β-defensin 2 is reversibly increasing microbiome diversity and is effective in the treatment of experimental colitis","year":2018,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Probiotics and Fermented Foods","field":"Agricultural and Biological Sciences","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Dysbiosis; Ulcerative colitis; Colitis; Microbiome; Immunology; Inflammatory bowel disease; Antimicrobial; Beta defensin; Defensin; Disease; Medicine; Gut flora; Antimicrobial peptides; Immune system; Biology; Innate immune system; Bioinformatics; Microbiology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001539625,0.0003126534,0.0004991193,0.0002742005,0.0001231397,0.0002857173,0.0001938491,0.0003727336,0.001457792],"category_scores_gemma":[0.0001037436,0.0001266565,0.0002648611,0.0002452338,0.0003156367,0.0002599045,0.0001558591,0.001034515,0.0002406321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001558113,"about_ca_system_score_gemma":0.0002329647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004764596,"about_ca_topic_score_gemma":0.0006190537,"domain_scores_codex":[0.9998263,0.0000254287,0.00001226515,0.00003578574,0.00004815029,0.00005218745],"domain_scores_gemma":[0.9999294,0.000007970545,0.00002084983,0.000006937099,0.000005154708,0.00002965543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005418627,0.001615123,0.0002086258,0.0002870717,0.00003340066,0.00007354269,0.00003677357,0.0002284635,0.9811516,0.0001010032,0.0003026742,0.01054297],"study_design_scores_gemma":[0.0009510589,0.02678942,0.007137053,0.00003361202,0.0001223251,0.0002155392,0.00009011804,0.001273133,0.9564716,0.00007814164,0.006816175,0.00002182248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953394,0.002444492,0.0006613707,0.0001646404,0.0001346128,0.00005907068,0.0003668574,0.00008351803,0.0007459343],"genre_scores_gemma":[0.9939088,0.002020874,0.0009302958,0.0001128902,0.00004207972,0.00007511071,0.0005488832,0.00001582624,0.002345244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001457792,"threshold_uncertainty_score":0.004876733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02037018775781092,"score_gpt":0.2463238742117152,"score_spread":0.2259536864539043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}