{"id":"W2793516758","doi":"10.1111/acel.12743","title":"<scp>NHR</scp> ‐49/ <scp>HNF</scp> 4 integrates regulation of fatty acid metabolism with a protective transcriptional response to oxidative stress and fasting","year":2018,"lang":"en","type":"article","venue":"Aging Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Pacific Centre for Reproductive Medicine; University of British Columbia","funders":"Canadian Institutes of Health Research; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; BC Children's Hospital","keywords":"Biology; Caenorhabditis elegans; Transcription factor; Cell biology; Nuclear receptor; Peroxisome proliferator-activated receptor; Regulation of gene expression; Transcriptional regulation; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008282705,0.0005358666,0.0002081155,0.0003392992,0.0002809613,0.0002298244,0.0003099836,0.0003489371,0.004020133],"category_scores_gemma":[0.0000649647,0.0001648352,0.000322589,0.0001242326,0.000360719,0.0001691799,0.0002863871,0.0005572804,0.001383999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000571515,"about_ca_system_score_gemma":0.0002515554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002031934,"about_ca_topic_score_gemma":0.004292121,"domain_scores_codex":[0.9998391,0.00001424058,0.000009125345,0.00004262294,0.00005841644,0.00003649856],"domain_scores_gemma":[0.9999201,0.000006767109,0.00002260486,0.00001296744,0.000006813924,0.00003071415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008018722,0.00001285107,0.00009611287,0.00001082419,0.000002780802,0.00006601577,0.00000312403,0.00004799655,0.9985737,0.0001029621,0.00008730361,0.0009162272],"study_design_scores_gemma":[0.00003309165,0.000094075,0.01219633,0.000008731798,0.0000123036,0.00038997,0.00002329234,0.001332266,0.9757991,0.00007695676,0.01002171,0.00001227837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811964,0.0008488962,0.006818003,0.0002154657,0.0001105086,0.00008712046,0.002835469,0.0006466933,0.007241455],"genre_scores_gemma":[0.9769333,0.0003460394,0.004132571,0.0001169408,0.00002286842,0.0000747207,0.003314097,0.0002122653,0.01484724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004020133,"threshold_uncertainty_score":0.01344866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00830502815042677,"score_gpt":0.2186276358568329,"score_spread":0.2103226077064062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}