{"id":"W2793533360","doi":"10.1371/journal.pone.0194880","title":"Testing therapeutics in cell-based assays: Factors that influence the apparent potency of drugs","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NHLBI Division of Intramural Research; Public Health Agency; Public Health Agency of Canada; National Institute of Allergy and Infectious Diseases; Battelle","keywords":"Potency; Ebola virus; EC50; Drug; Virus; Pharmacology; Cell; Drug discovery; In vitro toxicology; Bioassay; Virology; In vitro; Biology; Bioinformatics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002493417,0.00008992074,0.000177216,0.0001109547,0.00008032021,0.00001349927,0.0001036505,0.00005350643,0.00006151839],"category_scores_gemma":[0.0001446478,0.00005521091,0.00003608874,0.0004144355,0.0001724235,0.00004611588,0.00003630023,0.0002366322,0.00002263575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000510221,"about_ca_system_score_gemma":0.0001120389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009468745,"about_ca_topic_score_gemma":0.00004502385,"domain_scores_codex":[0.9989999,0.00005860811,0.0001789206,0.0001331527,0.0004167212,0.0002127026],"domain_scores_gemma":[0.9991236,0.0002525584,0.00006469263,0.0002540442,0.0002550873,0.00005000933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003633515,0.001233837,0.7471694,0.0001288396,0.00004576386,0.00000209196,0.0007404123,0.00001375874,0.2489761,0.000007655802,0.000007215574,0.001638635],"study_design_scores_gemma":[0.000592337,0.0006133197,0.44014,0.0003640146,0.00007731863,6.450047e-7,0.0004737542,0.003709465,0.5538411,0.00005095077,0.00005687544,0.00008021347],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943244,0.00008903829,0.00005555703,0.000410745,0.00001461824,0.0003179654,0.000004060908,0.00002629389,0.004757358],"genre_scores_gemma":[0.9991227,0.00001607298,0.0004013424,0.0002238728,0.00003933293,0.00001528868,0.00000313886,0.00001295486,0.0001652997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3070294,"threshold_uncertainty_score":0.2251436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1305588143249321,"score_gpt":0.3173370126288473,"score_spread":0.1867781983039153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}